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RRAD Antibody

  • 货号：
    CSB-PA233809
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HeLa cells, HepG2 cells and MCF-7 cells, using RAD antibody.
    • Immunohistochemistry analysis of paraffin-embedded human heart tissue using RAD antibody.
    • Immunofluorescence analysis of A549 cells, using RAD antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RRAD Polyclonal antibody
  • Uniprot No.：
    P55042
  • 基因名：
    RRAD
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human RAD.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
  • 基因功能参考文献：
    1. our study revealed that RRAD expression was decreased in Hepatocellular carcinoma (HCC) tumor tissues and predicted poor clinical outcome for HCC patients and played an important role in regulating aerobic glycolysis and cell invasion and metastasis and may represent potential targets for improving the treatment of HCC PMID: 26546438
    2. Brg1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating RRAD in aortic dissection. PMID: 26344687
    3. RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma. PMID: 25313011
    4. RRAD expression is frequently decreased in lung cancer. Ectopic expression of RRAD greatly reduces glycolysis whereas knockdown of RRAD promotes glycolysis in lung cancer cells. PMID: 25114038
    5. Rad suppresses the NF-Kappa-B mediated transcription and downstream gene activation. Rad can directly bind to RelA/p65 and suppress the interaction of RelA/p65 with the NF-kappa-B response DNA element. PMID: 24632303
    6. Ras(V12)-mediated oncogenic transformation induces RRAD epigenetic inactivation, which in turn promotes glucose uptake and may contribute to ovarian cancer PMID: 24648519
    7. RRAD hypermethylation is associated with esophageal squamous cell carcinoma. PMID: 24222170
    8. Mouse Rad Q65P (the murine equivalent of human Rad Q66P) inhibits L-type currents conducted by CaV1.2 or CaV1.3 channels as potently as wild-type Rad (>95% inhibition of both channels). PMID: 23973784
    9. Rad over expression could be a molecular target to improve bortezomib sensitivity in human leukemia and lymphoma. PMID: 22658652
    10. results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development PMID: 22487779
    11. the implication of oxidative stress in modulating Rad expression, in association with the initiation and progression of amyotrophic lateral sclerosis muscle atrophy PMID: 20079427
    12. It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 20460530
    13. crystallization and preliminary crystallographic analysis of human Rad GTPase PMID: 16511212
    14. Crystal structure of the GTPase domain of human Rad in the GDP-bound form at 1.8 A resolution. PMID: 16866878
    15. Methylation and gene silencing of the Ras-related GTPase gene is associated with lung and breast cancers PMID: 17195088
    16. Evidence from Rad transgenic mice suggests that the Rad-associated signaling pathway may play a role in arrhythmogenesis in diverse cardiac diseases. PMID: 17525370
    17. Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway PMID: 18056528
    18. occurrence of an unusual TG 3' splice site in intron 1 PMID: 17672918

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  • 亚细胞定位：
    Cell membrane.
  • 蛋白家族：
    Small GTPase superfamily, RGK family
  • 组织特异性：
    Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
  • 数据库链接：

    HGNC: 10446

    OMIM: 179503

    KEGG: hsa:6236

    STRING: 9606.ENSP00000299759

    UniGene: Hs.1027