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  4. RPS6KB2 Antibody

RPS6KB2 Antibody

  • 货号：
    CSB-PA020471GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBS0
  • 基因名：
  • 别名：
    70 kDa ribosomal protein S6 kinase 2 antibody; EC 2.7.11.1 antibody; KS6B2_HUMAN antibody; p70 beta antibody; p70 ribosomal S6 kinase beta antibody; p70 S6 kinase beta antibody; p70 S6K-beta antibody; p70 S6KB antibody; p70 S6Kbeta antibody; p70(S6K) beta antibody; p70-beta antibody; p70-S6K 2 antibody; P70S6K2 antibody; p70S6Kb antibody; Ribosomal protein S6 kinase 70kDa; polypeptide 2 antibody; Ribosomal protein S6 kinase B2 antibody; Ribosomal protein S6 kinase beta 2 antibody; Ribosomal protein S6 kinase beta-2 antibody; Rps6kb2 antibody; S6 kinase related kinase antibody; S6 kinase-related kinase antibody; S6K beta 2 antibody; S6K beta antibody; S6K-beta antibody; S6K-beta-2 antibody; S6K2 antibody; Serine/threonine protein kinase 14 beta antibody; Serine/threonine-protein kinase 14B antibody; SRK antibody; STK14B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RPS6KB2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.
  • 基因功能参考文献：
    1. Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency PMID: 28301598
    2. We propose that the S6K2/TRBP node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR pathway and the miRNA biogenesis machinery. PMID: 27407113
    3. discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer PMID: 24469061
    4. Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. PMID: 25124033
    5. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer. PMID: 24131622
    6. The p85 S6K1 promotes H2O2-induced cell death via a rapamycin-insensitive mechanism. PMID: 22955948
    7. S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis PMID: 23393338
    8. Study shows that the two homologues of S6K have distinct effects on Akt activation and cell survivalin breast cancer. PMID: 21427355
    9. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
    10. p70 S6 kinase regulates neutrophilic differentiation in HL-60 cells PMID: 12176053
    11. regulation of nucleocytoplasmic shuttling of S6KbetaII by protein kinase C-mediated phosphorylation PMID: 12529391
    12. the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells. PMID: 12818373
    13. These data suggest that activated p70 S6 kinase could mediate an up-regulation of tau translation. PMID: 12875979
    14. p70 ribosomal protein S6 kinase activity was induced by K-Ras in a phosphatidylinositol 3-kinase and mTOR-dependent manner. PMID: 14729629
    15. S6K2 is active throughout the cell cycle with higher activity in G2 and M phases. PMID: 17786541

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 数据库链接：

    HGNC: 10437

    OMIM: 608939

    KEGG: hsa:6199

    STRING: 9606.ENSP00000308413

    UniGene: Hs.534345