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RPN1 Antibody

  • 货号：
    CSB-PA020344GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P04843
  • 基因名：
  • 别名：
    D6Wsu137e antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit precursor antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 antibody; EC 2.4.1.119 antibody; Oligosaccharyltransferase 1 homolog antibody; oligosaccharyltransferase complex subunit (non-catalytic) antibody; OST1 antibody; RBPH1 antibody; Ribophorin I antibody; Ribophorin-1 antibody; RPN-I antibody; Rpn1 antibody; RPN1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RPN1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
  • 基因功能参考文献：
    1. These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway. PMID: 25451265
    2. Data indicate that malectin functions by forming a complex with ribophorin I. PMID: 22988243
    3. ribophorin I can regulate the delivery of precursor proteins to the OST complex by capturing substrates and presenting them to the catalytic core. PMID: 18607003
  • 亚细胞定位：
    Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族：
    OST1 family
  • 组织特异性：
    Expressed in all tissues tested.
  • 数据库链接：

    HGNC: 10381

    OMIM: 180470

    KEGG: hsa:6184

    STRING: 9606.ENSP00000296255

    UniGene: Hs.518244