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RPL10 Antibody

  • 货号：
    CSB-PA012538
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells, treated with Insulin (0.01u/ml, 15mins), using 60S Ribosomal Protein L10 antibody.
    • Western blot analysis of extracts from K562 cells (Lane 2), JK cells (Lane 3) and 293 cells (Lane 4), using 60S Ribosomal Protein L10 antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RPL10 Polyclonal antibody
  • Uniprot No.：
    P27635
  • 基因名：
    RPL10
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human 60S Ribosomal Protein L10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
  • 基因功能参考文献：
    1. The regulation of reactive oxygen species level by mitochondrial RPL10 is one of the major extra-ribosomal functions in pancreatic cancer cells, which could be used as an indicator for the tumorigenesis of pancreatic cancer. PMID: 30172100
    2. there are 7 mutations in RPL10 in 344 patients, or a mutation frequency of 2% PMID: 28428269
    3. A rare de novo mutation K78E is associated with severe syndromic intellectual disability and epilepsy. PMID: 29066376
    4. Mitochondrial Ribosomal Protein L10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells PMID: 27726420
    5. Our results expand the mutational and clinical spectrum of RPL10 identifying a new genetic cause of SED and highlight the emerging role of ribosomal proteins in the pathogenesis of neurodevelopmental disorders. PMID: 26290468
    6. report confirms the implication of RPL10 mutations in neurodevelopmental disorders and extends the associated clinical spectrum from autism to syndromic intellectual disability PMID: 25846674
    7. A mutation within the conserved N-terminal end of RPL10, a protein in close proximity to the peptidyl transferase active site of the 60S ribosomal subunit, causes severe defects in brain formation and function. PMID: 25316788
    8. Mutations affect the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias, with recurrent alterations of Arg98 in RPL10. PMID: 23263491
    9. mutation analysis of RPL10 in German patients with autism spectrum disorder PMID: 21567917
    10. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism PMID: 16940977
    11. QM binds to c-yes at the SH3 domain in tumor cell lines PMID: 12138090
    12. Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma PMID: 16331298
    13. Xq28 (QM gene) may be involved in ovary failure. PMID: 17566674
    14. A hexagonal crystal of L10CD was obtained by the sitting-drop vapour-diffusion method. The L10CD crystal diffracted to 2.5 A resolution and belongs to space group P3(1)21 or P3(2)21. PMID: 18007048
    15. Characteristic interactions among Arg90-Trp171-Arg139 guide the C-terminal part outside of the central fold PMID: 18258260
    16. Our results suggest that RPL10 has no major effect on the susceptibility to autism spectrum disorders PMID: 19166581

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  • 相关疾病：
    Autism, X-linked 5 (AUTSX5); Mental retardation, X-linked, syndromic, 35 (MRXS35)
  • 蛋白家族：
    Universal ribosomal protein uL16 family
  • 数据库链接：

    HGNC: 10298

    OMIM: 300847

    KEGG: hsa:6134

    STRING: 9606.ENSP00000341730

    UniGene: Hs.534404