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RPA4 Antibody

  • 货号：
    CSB-PA622640ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RPA4 antibody at 3μg/ml
      Lane 1: K562 whole cell lysate
      Lane 2: Mouse spleen tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 29 kDa
      Observed band size: 29 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA622640ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RPA4 Polyclonal antibody
  • Uniprot No.：
    Q13156
  • 基因名：
  • 别名：
    HSU24186 antibody; MGC120333 antibody; MGC120334 antibody; p30 antibody; Replication factor A protein 4 antibody; Replication protein A 30 kDa subunit antibody; RF A antibody; RF-A protein 4 antibody; RFA antibody; RFA4_HUMAN antibody; RP A antibody; RP-A p30 antibody; RPA antibody; RPA4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Replication protein A 30 kDa subunit protein (1-230AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
  • 基因功能参考文献：
    1. Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells. PMID: 19996105
    2. Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell. PMID: 19942684
    3. Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage. PMID: 15929725
  • 亚细胞定位：
    Nucleus. Note=Localizes to DNA repair foci after DNA damage.
  • 蛋白家族：
    Replication factor A protein 2 family
  • 组织特异性：
    Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.
  • 数据库链接：

    HGNC: 30305

    OMIM: 300767

    KEGG: hsa:29935

    STRING: 9606.ENSP00000362131

    UniGene: Hs.659349