ROR2 Antibody
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货号:CSB-PA020176
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规格:¥880
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其他:
产品详情
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Uniprot No.:Q01974
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基因名:
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别名:BDB antibody; BDB1 antibody; Brachydactyly type B antibody; EC 2.7.10.1 antibody; MGC163394 antibody; Neurotrophic tyrosine kinase antibody; Neurotrophic tyrosine kinase, receptor related 2 antibody; NTRKR2 antibody; Receptor tyrosine kinase-like orphan receptor 2 antibody; receptor-related 2 antibody; ROR2 antibody; ROR2_HUMAN antibody; Tyrosine protein kinase transmembrane receptor ROR2 antibody; Tyrosine-protein kinase transmembrane receptor Ror2 antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Synthesized peptide derived from the Internal region of Human ROR2.
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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产品提供形式:Liquid
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应用范围:WB, ELISA
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:5000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
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基因功能参考文献:
- Here, we show that Wnt/planar cell polarity (PCP) autocrine signaling controls the emergence of cytonemes, and that cytonemes subsequently control paracrine Wnt/beta-catenin signal activation. Upon binding of the Wnt family member Wnt8a, the receptor tyrosine kinase Ror2 becomes activated. PMID: 30060804
- Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following DeltaNp63beta-mediated EMT PMID: 28559016
- In squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder positive ROR2 or WNT5a expression is generally associated with a poor prognosis. PMID: 28465645
- Wnt5a suppressed osteoblastic differentiation through Ror2/JNK signaling in periodontal ligament stem cell-like cells. PMID: 28681925
- Data show that receptor tyrosine kinase-like orphan receptor 2 (ROR2) is epigenetically silenced by promoter hypermethylation in colorectal cancer cell lines and in early stages of colorectal neoplasia tissue. PMID: 27440078
- WNT5A and ROR2 are induced by inflammatory mediators through NF-kB and STAT3 transcription factors, and are involved in the migration of human ovarian cancer cell line SKOV-3. PMID: 28536612
- On these bases, we identified that miR-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR-208b can regulate the development of osteosarcoma. PMID: 28618961
- Our findings suggest that receptor tyrosine kinase-like orphan receptor 2 may be an important regulator of epithelial-mesenchymal transition, primarily regulated the non-canonical Wnt signaling pathway in ovarian cancer cells, and may display a promising therapeutic target for ovarian cancer. PMID: 28475014
- Knockdown of Ror2 expression in renal cell carcinoma cells significantly reduced cell proliferation and induced apoptosis. PMID: 28277191
- found no association between ROR2 staining and poor patient survival PMID: 27631337
- Data show that CD13 anntigen and receptor tyrosine kinase-like orphan receptor 2 (ROR2) identify a cardiac lineage precursor pool that is capable of successful engraftment into the porcine heart. PMID: 26771355
- ROR2 gene mutations are associated with autosomal recessive robinow syndrome. PMID: 26284319
- results corroborated previous findings of Ryk-mediated Wnt5a effect, and suggested a role for Ror2 in the Wnt5a machinery in glioblastoma PMID: 26596412
- Wnt5a-Ror2 signaling enhances expression and secretion of CXCL16 in mesenchymal stem cells thereby activating CXCR6 expressed on tumor cells to promote proliferation. PMID: 26708384
- We present strong evidence that ROR2 could be used as an indicator of poor prognosis and could represent a novel therapeutic target for PDAC. PMID: 26259918
- Findings suggest that high receptor tyrosine kinase-like orphan receptor (ROR) 2 or proto-oncogene protein Wnt-5A (Wnt5a) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC). PMID: 26305508
- These data suggest a mechanism where human cytomegalovirus alters the expression of the Wnt receptor ROR2 to alter Wnt5a-mediated signaling and inhibit trophoblast motility PMID: 26559837
- Positive ROR2 and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma. PMID: 25387569
- These results indicate that ROR2 is significantly correlated with cancer progression and poor prognosis in cervical cancer PMID: 25755786
- Mutations in key regions of the kinase domain of Ror2 resulted in the abrogation of increased tumor growth, cell migration, and cell invasion observed with expression of wild-type Ror2. PMID: 25542006
- High expression of the novel Wnt receptor ROR2 is associated with breast cancer. PMID: 25209439
- These results suggest that ROR2 expression is correlated with malignant attributes of CRC and may serve as an indicator for poor prognosis in patients with CRC. PMID: 25301559
- this paper reports the findings on three families with recessive Robinow syndrome which were identified in India. Three mutations in ROR2 gene, two novels and one previously known mutation were observed in these patients PMID: 24932600
- report a three-generation Chinese family with dominant inheritance of the BDB1 limb phenotype. Sequence analysis identified a novel heterozygous base deletion (c.1396-1398delAA) in the gene ROR2 in all affected family members PMID: 24954533
- ROR2 is an epigenetically inactivated tumor suppressor gene that antagonizes both beta-catenin and AKT signaling in multiple various carcinomas. PMID: 24158497
- a new role for Ror2 in conveying a tonic signal to stabilize soluble beta-catenin and create a poised state of enhanced responsiveness to Wnt3a exogenous signals in RCC. PMID: 23893409
- This study demonstrated the first attempt to identify Wnt5a and Ror2 as additional mechanisms contributing to dysregulation of the non-canonical WNT signaling pathway in medulloblastoma. Ror2 may play a role as an oncosuppressor in medulloblastoma. PMID: 23278988
- DEX induces the upregulation of noncanonical Wnt ligand Wnt5a. Recombinant WNT5a protein induces CLAN formation through the noncanonical Wnt receptor ROR2/RhoA/ROCK signaling axis. PMID: 23963164
- Sequence analysis of the gene ROR2 indicated a nonsense mutation (c.2278C>T, p.Q760X) in exon 9 in all brachydactyly type B affected individuals of the family. PMID: 23238279
- ROR2 expression was not seen in any of the hematological malignancies studied. PMID: 22988987
- review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field PMID: 23233346
- Our results do not support the relevance of ROR2/Wnt5a as biomarkers in stage 1 pure seminomas PMID: 23469623
- High ROR2 expression is involved in the pathophysiology of Multiple myeloma-induced bone disease. PMID: 22781592
- The unusual Asp-Leu-Gly motif in Ror2 is displaced compared with other inactive kinases, allowing the activation loop to interact directly with the tyrosine kinase domains. PMID: 22992069
- Molecular analysis of the ROR2 gene in a Lebanese family with a mild form of recessive Robinow syndrome revealed the presence of a previously undescribed missense mutation: p.R272C (c.814C>T), in the cysteine-rich domain of the protein. PMID: 22178368
- The present study provides evidence of the significant association between ROR2 variants and the OPG/RANKL ratio in human plasma and also suggests ROR2 association with hand osteoarthritis. PMID: 22057548
- Results provided evidence of linkage and association between the ROR2 gene and a gene controlling risk to non-syndromic cleft palate. PMID: 22490406
- Results show that ROR2 is a useful prognostic indicator in the clinical management of these soft-tissue sarcomas and may represent a novel therapeutic target. PMID: 22294416
- WNT-5a and ROR2 were more highly expressed in more severe disease states, and therefore may play a coordinated role in the occurrence and progression of osteosarcoma PMID: 22293903
- Data suggest that Wnt5a and Ror2 may serve as tumor suppressor genes in the development of hepatocellular carcinoma, and may serve as clinicopathologic biomarkers for prognosis in HCC patients. PMID: 22493546
- Wnt5a-Ror2 signaling might also be required for expression of MMP-13 gene during the development of the cartilaginous tissue. PMID: 22128168
- We report two mentally retarded female siblings and their cognitively normal father, all carrying a similar 5.3 Mb microdeletion at 9q22.2q22.32, involving 30 genes including the ROR2 gene and and SYK gene. PMID: 21693067
- 2265C>A mutation in ROR2 gene is associated with Brachydactyly type B1 in Chinese family. PMID: 21377971
- Results suggest that Wnt5a plays the role of a tumor suppressor in leukemogenesis through the Wnt5a/Ror2 noncanonical signaling pathway that inhibits Wnt canonical signaling. PMID: 21069266
- Results show expression of Wnt5a and Ror2 is induced during Snail-mediated epithelial-mesenchymal transition or malignant progression of cancer cells and that activated Wnt5a-Ror2 signaling confers highly motile and invasive properties on cancer cells. PMID: 21342370
- data show the importance of epigenetic alterations of ROR2 in colon cancer, highlighting the close interconnection between canonical and non-canonical Wnt signalling pathways in this type of tumour PMID: 20591152
- a unique regulation pattern for Ror2 in the VHL-HIF axis that has the potential to be applied to other cancer etiologies. PMID: 20185829
- Data showed a correlation between the severity of BDB1, the location of the mutation, and the amount of membrane-associated ROR2. PMID: 19640924
- The deletion represents the second ROR2 mutation associated with a autosomal dominant brachydactyly type B1-syndactyly phenotype. PMID: 19461659
- Data show that ROR2 knockdown results in a decrease in signaling downstream of Wnt5A. PMID: 19802008
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相关疾病:Brachydactyly B1 (BDB1); Robinow syndrome autosomal recessive (RRS)
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亚细胞定位:Cell membrane; Single-pass type I membrane protein.
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蛋白家族:Protein kinase superfamily, Tyr protein kinase family, ROR subfamily
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数据库链接:
HGNC: 10257
OMIM: 113000
KEGG: hsa:4920
STRING: 9606.ENSP00000364860
UniGene: Hs.644776
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