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ROBO2 Antibody

  • 货号：
    CSB-PA888028ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate, Ntera-2 whole cell lysate
      All lanes: ROBO2 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 131, 152, 154 kDa
      Observed band size: 152 kDa
  • 其他：

产品详情

  • 产品描述：

    The production of anti-ROBO2 antibody involves immunizing rabbits with recombinant human ROBO2 protein (450-660aa), collecting the resulting blood to isolate the anti-serum, and purifying the antibody through antigen affinity purification.

    The resulting ROBO2 polyclonal antibody is a type of unconjugated IgG. It only recognizes the human ROBO2 protein, which plays a crucial role in axon guidance, cell migration, angiogenesis, and tumor progression. This antibody has undergone validation for use in both ELISA and WB applications, allowing for the detection of the quantity and presence of the ROBO2 protein.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ROBO2 Polyclonal antibody
  • Uniprot No.：
    Q9HCK4
  • 基因名：
    ROBO2
  • 别名：
    lea antibody; Robo 2 antibody; Robo2 antibody; ROBO2_HUMAN antibody; Roundabout 2 antibody; Roundabout homolog 2 antibody; roundabout, axon guidance receptor, homolog 2 (Drosophila) antibody; Roundabout2 antibody; SAX 3 antibody; SAX3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Roundabout homolog 2 protein (450-660AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
  • 基因功能参考文献：
    1. determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4 PMID: 29017837
    2. ROBO2 variants were not found to be associated with nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia, providing further evidence for genetic heterogeneity PMID: 27002985
    3. ROBO2 and RASSF2A gene methylations may be related to gastric tumorigenesis, and ROBO2 gene methylation is associated with sporadic gastric cancer. PMID: 27461616
    4. Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer PMID: 26542734
    5. ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired. PMID: 26608094
    6. Common variation near ROBO2 is associated with expressive vocabulary in infancy. PMID: 25226531
    7. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract PMID: 26026792
    8. Down-regulation of ROBO2 expression is associated with prostate cancers. PMID: 24272677
    9. The finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy. PMID: 23982283
    10. Results not completely rule out that some ROBO2 variants may be the sole cause of vesicoureteric reflux, but it is clear from the overall frequency that most of them cannot be. PMID: 23536131
    11. two differentially expressed isoforms were isolated and identified. Exons 1 and 2 of human ROBO2a lie in an inherently unstable DNA segment at human chromosome 3p12.3. PMID: 16829019
    12. Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. PMID: 17357069
    13. a relatively high frequency of ROBO2 variants (5.1%) was found in familial vesicoureteral reflux PMID: 18235093
    14. mRNA expression of ROBO2 in lymphocytes was significantly reduced in the autistic group PMID: 18270976
    15. gene variants in ROBO2 are rare causes of VUR in humans. Our results provide further evidence for the genetic heterogeneity of this disorder PMID: 19350278

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  • 相关疾病：
    Vesicoureteral reflux 2 (VUR2)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, ROBO family
  • 数据库链接：

    HGNC: 10250

    OMIM: 602431

    KEGG: hsa:6092

    STRING: 9606.ENSP00000417335

    UniGene: Hs.13305