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RNMT Antibody

  • 货号：
    CSB-PA019902GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O43148
  • 基因名：
    RNMT
  • 别名：
    DKFZp686H1252 antibody; EC 2.1.1.56 antibody; hcm1p antibody; hCMT1 antibody; HCMT1a antibody; hCMT1c antibody; hMet antibody; hypothetical protein KIAA0396 antibody; KIAA0398 antibody; MCES_HUMAN antibody; MET antibody; mRNA (guanine 7)methyltransferase antibody; mRNA (guanine N(7)) methyltransferase antibody; mRNA (guanine-N(7)-)-methyltransferase antibody; mRNA cap guanine-N7 methyltransferase antibody; mRNA cap methyltransferase antibody; OTTHUMP00000162509 antibody; RG7MT1 antibody; RNA (guanine 7) methyltransferase antibody; RNA guanine 7 methyltransferase antibody; Rnmt antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RNMT
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
  • 基因功能参考文献：
    1. Results identify a cytoplasmic pool of RNMT which is a component of the cytoplasmic capping complex, and demonstrate its function as the methyltransferase that catalyzes the final maturation step in cap homeostasis. PMID: 28981715
    2. MYC promotes mRNA cap methylation and protein production of Wnt/beta-catenin signaling transcripts through recruitment of cyclin-dependent kinase 7 (CDK7) and consequently RNMT to gene promoters. PMID: 27899423
    3. RNMT-RAM complex coordinates mRNA processing with ribosome production. PMID: 27934633
    4. CDK1-Cyclin B1 activates RNMT, coordinating mRNA cap methylation with G1 phase transcription. PMID: 26942677
    5. High RNMT expression is associated with liver cancer. PMID: 24763612
    6. Data suggest the C-terminal nuclear localization domain (QYP) is critical for RAM (RNMT-activating mini protein) to enter the cell nucleus where RAM activates RNMT resulting in mRNA cap methylation. TNPO1/TNPO2 mediate RAM nuclear entry. PMID: 24200467
    7. The RNMT N-terminal domain is required for transcript expression, translation and cell proliferation. PMID: 23863084
    8. Nuclear localization of cap methyltransferase is mediated by alternative nuclear localization signal motifs PMID: 15767670

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, mRNA cap 0 methyltransferase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 10075

    OMIM: 603514

    KEGG: hsa:8731

    STRING: 9606.ENSP00000262173

    UniGene: Hs.592347