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RNGTT Antibody

  • 货号：
    CSB-PA526449ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RNGTT antibody at 1.42µg/ml + THP-1 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 69, 67, 53, 62 kDa
      Observed band size: 69 kDa
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA526449ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RNGTT Polyclonal antibody
  • Uniprot No.：
    O60942
  • 基因名：
    RNGTT
  • 别名：
    CAP1A antibody; GTase antibody; GTP--RNA guanylyltransferase antibody; hCAP antibody; HCAP1 antibody; HcE antibody; HCE1 antibody; MCE1 antibody; MCE1_HUMAN antibody; mRNA 5''-triphosphatase antibody; mRNA capping enzyme antibody; mRNA guanyltransferase antibody; mRNA guanylyltransferase antibody; Polynucleotide 5' trisphosphatase antibody; RNA guanylyltransferase and 5' phosphatase antibody; RNGTT antibody; TPase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human mRNA-capping enzyme protein (1-260AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
  • 基因功能参考文献：
    1. c-Myc deregulation induces mRNA capping enzyme dependency in tumor cells. PMID: 27756891
    2. These results identify a new domain of CE that is specific to its function in cytoplasmic capping, and a new role for Nck1 in regulating gene expression through its role as the scaffold for assembly of the cytoplasmic capping complex. PMID: 25137142
    3. Our biochemical studies provide the first insight that MZP can inhibit the formation of the RNA cap structure catalyzed by HCE. PMID: 23349942
    4. Data show that human capping enzyme residues 229-567 comprise the minimum enzymatically active human GTase (hGTase) domain and determine the structure by X-ray crystallography. PMID: 21636784
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family
  • 组织特异性：
    Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
  • 数据库链接：

    HGNC: 10073

    OMIM: 603512

    KEGG: hsa:8732

    STRING: 9606.ENSP00000358497

    UniGene: Hs.567378