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RNF43 Antibody

  • 货号：
    CSB-PA019892LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA019892LA01HU diluted at 1:600 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RNF43 Polyclonal antibody
  • Uniprot No.：
    Q68DV7
  • 基因名：
  • 别名：
    RNF43 antibody; E3 ubiquitin-protein ligase RNF43 antibody; EC 2.3.2.27 antibody; RING finger protein 43 antibody; RING-type E3 ubiquitin transferase RNF43 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF43 protein (566-697AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RNF43 Antibody (CSB-PA019892LA01HU)，的标记方式是Non-conjugated。对于RNF43 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019892LB01HU RNF43 Antibody, HRP conjugated ELISA
    FITC CSB-PA019892LC01HU RNF43 Antibody, FITC conjugated
    Biotin CSB-PA019892LD01HU RNF43 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
  • 基因功能参考文献：
    1. results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers PMID: 29769720
    2. Data suggest that inactivation of RNF43 and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype. PMID: 27661107
    3. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. PMID: 27461012
    4. RNF43 mutation constitutes an important mutated driver gene for the Serrated Neoplasia pathway in both the sporadic and familial Polyposis settings. PMID: 27329244
    5. RNF43 is down-regulated in intrahepatic cholangiocarcinoma and may play a crucial role during development of ICC. PMID: 26980022
    6. The finding of RNF43 mutation in sessile serrated adenoma and traditional serrated adenoma, but not in tubulovillous/villous adenoma, indicated that RNF43 mutation is an early and specific molecular aberration in the serrated colorectal carcinoma pathway. PMID: 27305845
    7. Mutations and downregulation of RNF43 may play a critical role in the transition from adenoma to carcinoma. PMID: 27514024
    8. PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs). PMID: 26924569
    9. our study exhibited the expression patterns and correlation of RNF43 and p53 pathway proteins involved in cell cycling PMID: 26823834
    10. s also identified ring finger 43 (RNF43), an inhibitor of Wnt/beta-catenin signaling, as a target of miR-550a-5p. PMID: 25961913
    11. RNF43 inhibits the Wnt pathway downstream of oncogenic mutations that activate the pathway. PMID: 26350900
    12. RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis PMID: 26184844
    13. RNF43 gene harbored not only exceedingly high mutations but also mutational intratumoral heterogeneity, which together might play a role in tumorigenesis of gastric and colorectal cancers. PMID: 26297255
    14. The nucleoprotein of influenza A virus targets RNF43 to modulate p53 ubiquitination levels and hence causes p53 stabilization which is conducive to an enhanced apoptosis level in the host cells. PMID: 25996295
    15. we found that the decreased expression of RNF43 in glioma was associated with poor prognosis by the Kaplan-Meier survival analysis. Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival. PMID: 25755738
    16. These results indicate that RNF43 mutation might cause downregulation of the expression of ring finger protein 43 and play a crucial role during development of intraductal papillary mucinous neoplasm of the pancreas. PMID: 25081753
    17. Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity. PMID: 25891077
    18. Missense mutations of RNF43 change their localization from the endosome to the endoplasmic reticulum. PMID: 25825523
    19. RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers PMID: 25344691
    20. Signalling potency of R-spondin proteins depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2 PMID: 24225776
    21. RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer. PMID: 24001777
    22. mutational inactivation of RNF43 in pancreatic adenocarcinoma confers Wnt dependency PMID: 23847203
    23. RNF43 is involved in tumorigenesis and progression of human hepatocellular carcinoma. PMID: 23136185
    24. RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary. PMID: 23096461
    25. RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation PMID: 22895187
    26. These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis. PMID: 21108931
    27. RNF43 may exert its growth promoting effect in an antocrine manner and may be a novel diagnostic marker for colorectal cancer PMID: 15492824
    28. These results infer that RNF43 is a resident protein of the ER and, at least partially, the nuclear membrane, with ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with HAP95. PMID: 18313049

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  • 相关疾病：
    Sessile serrated polyposis cancer syndrome (SSPCS)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope.
  • 蛋白家族：
    ZNRF3 family
  • 组织特异性：
    Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
  • 数据库链接：

    HGNC: 18505

    OMIM: 612482

    KEGG: hsa:54894

    STRING: 9606.ENSP00000385328

    UniGene: Hs.584916