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RNF181 Antibody

  • 货号：
    CSB-PA019860GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9P0P0
  • 基因名：
    RNF181
  • 别名：
    RNF181 antibody; HSPC238 antibody; E3 ubiquitin-protein ligase RNF181 antibody; EC 2.3.2.27 antibody; RING finger protein 181 antibody; RING-type E3 ubiquitin transferase RNF181 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RNF181
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
  • 基因功能参考文献：
    1. The identification and validation of proteins interacting with HSP238 may lead to the discovery of novel mechanisms through which HSPC238 suppresses tumorigenesis in human hepatocellular carcinoma PMID: 26398855
    2. RNF181 limits the proliferation of human diffuse large B cell lymphoma cells that depend upon aberrant CARD11 signaling to NF-kappaB for growth and survival in culture. PMID: 26711259
    3. RN181 suppresses the tumorigenesis of hepatocellular carcinoma through the inhibition of ERK/MAPK signaling in the liver. PMID: 21391225
    4. Data show LOC51255 (RNF181) protein located in the cytoplasm of HePG2 cell line. PMID: 19426595
    5. The presence of RN181 in human platelets was established; RN181 has ubiquitin E3 ligase activity. PMID: 18331836

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  • 蛋白家族：
    RNF181 family
  • 组织特异性：
    Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).
  • 数据库链接：

    HGNC: 28037

    OMIM: 612490

    KEGG: hsa:51255

    STRING: 9606.ENSP00000306906

    UniGene: Hs.356187