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  4. RNF14 Antibody

RNF14 Antibody

  • 货号：
    CSB-PA080036
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBS8
  • 基因名：
    RNF14
  • 别名：
    Androgen receptor associated protein 54 antibody; Androgen receptor-associated protein 54 antibody; ARA 54 antibody; ARA54 antibody; E3 ubiquitin protein ligase RNF14 antibody; E3 ubiquitin-protein ligase RNF14 antibody; FLJ26004 antibody; HFB 30 antibody; HFB30 antibody; HRIHFB2038 antibody; RING finger protein 14 antibody; RNF 14 antibody; Rnf14 antibody; RNF14_HUMAN antibody; TRIAD 2 antibody; TRIAD2 antibody; Triad2 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human ARA54.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
  • 基因功能参考文献：
    1. Ring Finger Protein 14 (RNF14) is a binding partner for all TCF/LEF transcription factors. PMID: 23449499
    2. dominant-negative AR coregulator can suppress AR transactivation and cell proliferation in prostate cancer cells PMID: 11673464
    3. ARA54 role in prostate carcinoma progression may in may involve function as androgen receptor coactivator and focal adhesion protein PMID: 12772188
    4. ARA54, might have dual in vivo roles functioning as both a direct coactivator and as an indirect mediator in AR function. PMID: 17082327
    5. Dual functional roles for ARA54 as an AR coregulator directly and as a mediator for the suppressive effect of hnRNP A1 indirectly. PMID: 17110431
    6. mRNA expression of ARA54 correlates with that of cyclin D1 in human colon carcinoma cells, indicating that ARA54 is not only involved in the regulation of cyclin D1 expression in cultured cell lines but also in clinical cancer specimens. PMID: 17510080
    7. Differential localization of ARA54 may play an important role in testicular development and spermatogenesis in humans. PMID: 17919607

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    RBR family, RNF14 subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 10058

    OMIM: 605675

    KEGG: hsa:9604

    STRING: 9606.ENSP00000324956

    UniGene: Hs.483616