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RING1 Antibody

  • 货号：
    CSB-PA205793
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extract from Hela cells using Ring1A Antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RING1 Polyclonal antibody
  • Uniprot No.：
    Q06587
  • 基因名：
    RING1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around aa.35~39( I-A-V-S-P) derived from Human Ring1A.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
  • 基因功能参考文献：
    1. High RING1 expression is associated with hepatocellular carcinoma. PMID: 29187402
    2. Mutation of RING1 is associated with neurodevelopmental abnormalities PMID: 29386386
    3. study identified novel interactions between CD147 and RING1, recovered CD147 nuclear envelope distribution in melanoma cells, and suggested a new mechanism underlying how cytoplasmic CD147 promotes melanoma development PMID: 28832687
    4. The release of epigenetic repression by nitrosylation of RING1A is critical for effective cell transdifferentiation. PMID: 27623813
    5. The polycomb complex proteins BMI1 and RING1A regulate the ubiquitination of chromatin associated proteins bound to promoters. PMID: 26578590
    6. On the basis of these results, we proposed that the expression of Ring1 protein may be a novel indicator of hepatocellular carcinoma prognosis. PMID: 26141041
    7. High RING1 expression is associated with non-small cell lung cancer. PMID: 24414991
    8. HSCARG interacts with RING1 and inhibits RING1 ubiquitination. PMID: 24711370
    9. Overexpression of the EZH2, RING1, and BMI1 genes is common in MDS and indicate poor prognosis. The products of these genes might participate in epigenetic regulation of Myelodysplastic syndromes. PMID: 21125401
    10. USP7 was identified as a deubiquitinating enzyme that regulates the ubiquitination state of RING1B. PMID: 20800574
    11. PcG protein RING1 is associated with adverse pathological features and clinical PSA recurrence in prostate cancer. PMID: 17134822
    12. Studies in mammalian cells have found a multiplicity of protein complexes containing Ring1A and Ring1B, suggesting an expanded regulatory role for Ring1A, Ring1B proteins in the epigenetic regulation of gene expression. PMID: 19412891

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  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 数据库链接：

    HGNC: 10018

    OMIM: 602045

    KEGG: hsa:6015

    STRING: 9606.ENSP00000363787

    UniGene: Hs.631989