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RIMS2 Antibody

  • 货号：
    CSB-PA019723GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQ26
  • 基因名：
    RIMS2
  • 别名：
    KIAA0751 antibody; Non small cell lung cancer RimL3a protein antibody; Non small cell lung cancer RimL3c protein antibody; OBOE antibody; Protein regulating synaptic membrane exocytosis 2 antibody; Rab-3-interacting molecule 2 antibody; Rab-3-interacting protein 3 antibody; Rab3 interacting molecule 2 antibody; RAB3IP3 antibody; Regulating synaptic membrane exocytosis 2 antibody; Regulating synaptic membrane exocytosis protein 2 antibody; RIM 2 antibody; Rims2 (gene name) antibody; Rims2 antibody; RIMS2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RIMS2-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.
  • 基因功能参考文献：
    1. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47. PMID: 28377503
    2. Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux PMID: 22248876
    3. These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 gating kinetics in immature cochlear inner hair cells. PMID: 20363327
    4. Western blot analysis shows increased RIMS2 protein expression in the amygdala in schizophrenia. PMID: 18490030
    5. tick-borne encephalitis virus -NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1) PMID: 19199833

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.
  • 组织特异性：
    Widely expressed. Expressed in melanocytes. In fetal tissues, predominantly expressed in the brain. In the retina, expressed in the outer plexiform layer (at protein level). In the cerebellum, expressed in Purkinje cells (at protein level). In the pancrea
  • 数据库链接：

    HGNC: 17283

    OMIM: 606630

    KEGG: hsa:9699

    UniGene: Hs.655271