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  4. RICTOR Antibody

RICTOR Antibody

  • 货号：
    CSB-PA917257
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA917257(RICTOR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA917257(RICTOR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q6R327
  • 基因名：
  • 别名：
    AVO3 antibody; AVO3 homolog antibody; DKFZp686B11164 antibody; hAVO3 antibody; KIAA1999 antibody; Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody; mAVO3 antibody; MGC39830 antibody; PIA antibody; Pianissimo antibody; Rapamycin insensitive companion of mTOR antibody; Rapamycin-insensitive companion of mTOR antibody; Rictor antibody; RICTR antibody; RICTR_HUMAN antibody; RPTOR independent companion of MTOR complex 2 antibody; TORC2 specific protein AVO3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human RICTOR
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
  • 基因功能参考文献：
    1. Rictor striatal levels could counteract neuronal dysfunction induced by mutant huntingtin. PMID: 29460266
    2. High Rictor expression is associated with gastric cancer. PMID: 29328491
    3. Down-regulation of miR-142-3p inhibited ECs apoptosis and atherosclerotic development by up-regulating the expression of Rictor and activating the Akt/eNOS signaling pathway. PMID: 29949787
    4. Rictor regulates the vasculogenic mimicry of melanoma and determines the patients' survival via the AKT-MMP2-MMP9 pathway. PMID: 28699701
    5. Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism. PMID: 28475179
    6. Tumor-suppressive microRNA-218 inhibits tumor angiogenesis through RICTOR/VEGFA axis in prostate tumor cells. PMID: 28030804
    7. Results find RICTOR frequently amplified in small cell lung cancer (SCLC) tumors and associated with decreased survival. PMID: 27863413
    8. Study examined mTOR variables, with attention to mTORC2 (Rictor), in Alzheimer's disease (AD) brain samples and in two mouse models, and made comparisons with results from cell- and in vitro-based experiments where Abeta is either expressed or peptide added. s conclude that striking a new balance by restoring mTORC2 abundance and/or inhibition of mTORC1 has therapeutic potential in AD. PMID: 28035937
    9. Missense mutation in RICTOR gene is associated with Tourette syndrome. PMID: 28608572
    10. RICTOR amplification is a rare but therapeutically relevant genomic alteration across solid tumors. Our results support further pre-clinical and clinical investigation with AZD2014 in RICTOR amplified gastric cancer and highlights the importance of genomic profiling PMID: 28028034
    11. miR-153 downregulation could be one important reason of Rictor upregulation and mTORC2 over-activation in glioma cells. Further, miR-153-induced anti-glioma cell activity is possibly via downregulating Rictor. PMID: 27295037
    12. These results point to an increase in total and phosphorylated Akt in high-grade gliomas and to a possible role of RICTOR in proliferations of high-grade glioblastomas cells. PMID: 27789731
    13. Hgh mTOR activity and Rictor overexpression could be markers of a bad prognosis. Combined phosphoprotein and Rictor/Raptor expression evaluation revealed even stronger statistical correlation with prognosis. PMID: 27729429
    14. In this study we began by validating the expression of four main mTOR pathway components, mTOR, DEPTOR, rictor and raptor, at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer PMID: 27211906
    15. Based on univariate and multivariate Cox proportional hazards regression analysis, RICTOR-positive expression, AJCC staging III or IV and nodal metastasis are prognostic factors and the former two are independent risk factors for esophageal squamous cell carcinoma. PMID: 28132115
    16. Taken together, our results suggest that the proinflammatory cytokine TNFalpha promotes the expression of Rictor through the NF-kappaB pathway in renal cell carcinoma. PMID: 26500094
    17. RICTOR amplification may define a novel and unique molecular subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors. PMID: 26370156
    18. Data show that rapamycin-insensitive companion of mTOR protein (RICTOR) plays a central role in phosphatidylinositol 3-kinase (PI3K)/proto-oncogene protein c-akt (AKT) pathway in melanocytes and its deregulation could be involved in melanoma development. PMID: 26356562
    19. Mdm20 acts as a novel regulator of Rictor, thereby controlling mTORC2 activity, and leading to the activation of PKCalphaS657 and FoxO1. PMID: 26600389
    20. RICTOR/MTORC2-AKT can integrate convergent hormonal and metabolic signals to provide coordinated and sensitive regulation of hepatic FOXO1-target gene expression. PMID: 26453307
    21. the expressions of Beclin1, Raptor, and Rictor are related to the development and progression of colorectal carcinoma and multidrug resistance. PMID: 26363527
    22. A new dimension in mTOR-rictor relationship. PMID: 25893736
    23. phosphorylation of Rictor at Ser1162 by Plk1 might be involved in a novel signaling pathway. PMID: 25714006
    24. results suggest that mTORC2/Rictor/pAkt may play a more important role than mTORC1/pS6 in tumor progression, which could act as a prognostic biomarker or potential therapeutic target in gastric cancer PMID: 26159923
    25. glucose-dependent acetylation of Rictor, a central component of mechanistic target of rapamycin complex 2 (mTORC2), promotes tumor growth and resistance to epidermal growth factor receptor (EGFR)-, PI3K-, and AKT-targeted therapies PMID: 26170313
    26. analysis of how Rictor undergoes GSK3-dependent, FBXW7-mediated ubiquitination and proteasomal degradation PMID: 25897075
    27. these data provide evidence that rictor is a multifunctional signaling regulator that can regulate FcepsilonRI-mediated degranulation independently of mTORC2. PMID: 25378594
    28. Rictor is an independent prognostic factor for endometrial carcinoma. PMID: 24966915
    29. Rictor contributes to cisplatin resistance in human ovarian cancer cells by suppressing cisplatin-induced apoptosis and by activating and stabilizing Akt. PMID: 24086535
    30. Data indicate mTOR kinase-independent function and mechanism of Rictor in the regulation of neutrophil chemotaxis, and suggest that the small Rho GTPases Rac and Cdc42 serve as downstream effectors of Rictor to regulate actin assembly. PMID: 24006489
    31. These data provide a novel mechanistic link of Nox4-dependent activation of mTORC2 via the energy sensor AMP-activated protein kinase to increased proliferation and survival of PAVSMCs in pulmonary artery hypertension. PMID: 24270265
    32. IKK interacts with rictor and regulates the function of mTORC2 including phosphorylation of AKT (at Serine473) and organization of actin cytoskeleton. PMID: 23872070
    33. The expression of Raptor was associated with a higher tumour grade. PMID: 23503572
    34. NBS1 interacts with the mTOR/Rictor/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt activity. PMID: 23762398
    35. combined silencing of EGFR and Rictor should be an effective means of treating glioblastoma PMID: 23555046
    36. Histolopathological and clinical information including tumour stage, invasion characteristic and endocrine status were analysed against the gene transcript expression of mTOR, RAPTOR and RICTOR. PMID: 23898069
    37. Rictor by suppressing RhoGDI2 promotes activity of the Rho proteins and cell migration. PMID: 22777355
    38. High rictor expression is associated with hemangioendothelioma. PMID: 23067215
    39. Reduced mTORC2 activity impairs both long-term memory and the late phase of hippocampal long-term potentiation. PMID: 23455608
    40. analysis of the role of RICTOR in beta1 integrin-mediated cell survival and how receptor-specific mechanisms regulate phosphorylation of AKT at Ser473 PMID: 22384145
    41. RICTOR overexpression in sarcomas and its links to therapeutic response need to be assessed PMID: 22080063
    42. multiple-site acetylation of Rictor signals for increased activation of mTORC2, providing a critical link between nutrient-sensitive deacetylases and mTORC2 signaling to Akt PMID: 22084251
    43. these results suggest that elevated growth factor signaling may contribute to decrease rictor/FBXW7-mediated ubiquitination of c-Myc and cyclin E, thus leading to accumulation of cyclin E and c-Myc in colorectal cancer cells. PMID: 22285861
    44. Rictor is a novel target of miR-218, suggesting that activation of the mTOR-Akt signaling pathway induced by Rictor contributes centrally to oral carcinogenesis. PMID: 21795477
    45. in response to cellular stress, GSK-3beta restrains mTORC2-Akt signaling by specifically phosphorylating rictor, thereby balancing the activities of GSK-3beta and Akt, two opposing players in glucose metabolism PMID: 21343617
    46. PINK1 exerts its cytoprotective function not only in mitochondria but also in the cytoplasm through activation of mTORC2 PMID: 21177249
    47. Fndings identify Rictor as an important mediator of chemotaxis and metastasis in breast cancer cells. PMID: 20978191
    48. Rictor phosphorylation takes place in mammalian target of rapamycin (mTORC)2-deficient cells; this modification may play a role in regulating not only mTORC2 but also the mTORC2-independent function of rictor. PMID: 20501647
    49. There is an increased mitochondrial dependence upon mTORC2 dependent cell growth due to PTEN loss PMID: 21170086
    50. there are two parallel cell-survival pathways in prostate cancer cells: a strong Akt-independent, but rapamycin-sensitive pathway downstream of mTORC1, and an AR-dependent pathway downstream of mTORC2 and Akt, that is stimulated by mTORC1 inhibition PMID: 18776922

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  • 蛋白家族：
    RICTOR family
  • 数据库链接：

    HGNC: 28611

    OMIM: 609022

    KEGG: hsa:253260

    STRING: 9606.ENSP00000349959

    UniGene: Hs.407926