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RHOQ Antibody

  • 货号：
    CSB-PA019693GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P17081
  • 基因名：
  • 别名：
    ARHQ antibody; Ras homolog gene family member Q antibody; RAS like family 7 member A antibody; Ras like protein family member 7A antibody; Ras like protein TC10 antibody; Ras related GTP binding protein TC10 antibody; Ras-like protein family member 7A antibody; Ras-like protein TC10 antibody; RASL7A antibody; Rho related GTP binding protein RhoQ antibody; Rho-related GTP-binding protein RhoQ antibody; Rhoq antibody; RHOQ_HUMAN antibody; TC10A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RHOQ
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
  • 基因功能参考文献：
    1. Exocytosis of Rab11- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth PMID: 24223996
    2. Novel tumor-associated increase of RNA editing in ras homologue family member Q (RHOQ) transcripts, is reported. PMID: 24663214
    3. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin PMID: 12687004
    4. Overexpression of the Rho family member TC10alpha, disrupts adipocyte cortical actin structure and inhibits insulin-stimulated GLUT4 translocation PMID: 12972548
    5. The GTP-bound form of TC10 directs the trafficking of CFTR from the juxtanuclear region to the secretory pathway toward the plasma membrane PMID: 15546864
    6. The crystal structure of TC10 proved that the basic region of WASp and two unique glutamates in Cdc42 generate favorable electrostatic steering forces that control the accelerated WASp-Cdc42 association reaction. PMID: 16246732
    7. We propose that an EGF-stimulated GAP accelerates GTP hydrolysis of TC10, thereby promoting vesicle fusion. PMID: 16950130
    8. These findings reveal a novel signaling pathway in human skeletal muscle that involves obscurin and the Rho GTPase TC10 and implicate this pathway in new sarcomere formation. PMID: 19258391

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 数据库链接：

    HGNC: 17736

    OMIM: 605857

    KEGG: hsa:23433

    STRING: 9606.ENSP00000238738

    UniGene: Hs.709193