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RHOJ Antibody

  • 货号：
    CSB-PA872495LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA872495LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RHOJ Polyclonal antibody
  • Uniprot No.：
    Q9H4E5
  • 基因名：
    RHOJ
  • 别名：
    ARHJ antibody; Ras homolog family member J antibody; Ras homolog gene family member J antibody; RAS like family 7 member B antibody; Ras like protein family member 7B antibody; Ras-like protein family member 7B antibody; RASL 7B antibody; RASL7B antibody; Rho related GTP binding protein RhoJ antibody; Rho-related GTP-binding protein RhoJ antibody; RHOI antibody; Rhoj antibody; RHOJ_HUMAN antibody; Tc10 like GTP binding protein TCL antibody; TC10 like Rho GTPase antibody; Tc10-like GTP-binding protein antibody; TC10B antibody; TCL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rho-related GTP-binding protein RhoJ protein (1-211AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RHOJ Antibody (CSB-PA872495LA01HU)，的标记方式是Non-conjugated。对于RHOJ Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872495LB01HU RHOJ Antibody, HRP conjugated ELISA
    FITC CSB-PA872495LC01HU RHOJ Antibody, FITC conjugated
    Biotin CSB-PA872495LD01HU RHOJ Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration.
  • 基因功能参考文献：
    1. Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ signaling halts the growth of BRAF mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism. As up to 50% of BRAF mutant human melanomas express high levels of RhoJ, these studies nominate the RhoJ-BAD signaling network as a therapeutic vulnerability for fledgling BRAF mutant human tumor PMID: 28753606
    2. These results identify amino acids within the N terminus and a loop region distal to the nucleotide binding pocket of TCL capable of allosterically regulating nucleotide exchange and thus influence membrane association of the protein. PMID: 27660391
    3. FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site. PMID: 26299518
    4. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility. PMID: 24928894
    5. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects. PMID: 24434213
    6. These observations identify RHOJ as a melanoma linchpin determinant that regulates both actin cytoskeletal dynamics and chemoresistance by activating PAK1. PMID: 23253891
    7. Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility. PMID: 23029280
    8. we identified RhoJ and its effector PAK1, as key modulators of melanoma cell sensitivity to DNA damage PMID: 22971344
    9. Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation PMID: 21628409
    10. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers. PMID: 21148427
    11. TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes PMID: 12960428

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 组织特异性：
    Specifically expressed in endothelial cells in different tissues, such as brain, heart, lung and liver.
  • 数据库链接：

    HGNC: 688

    OMIM: 607653

    KEGG: hsa:57381

    STRING: 9606.ENSP00000316729

    UniGene: Hs.656339