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RHBDL2 Antibody

  • 货号：
    CSB-PA019672LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019672LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RHBDL2 Polyclonal antibody
  • Uniprot No.：
    Q9NX52
  • 基因名：
    RHBDL2
  • 别名：
    RHBDL2 antibody; Rhomboid-related protein 2 antibody; RRP2 antibody; EC 3.4.21.105 antibody; Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2 antibody; N-terminal fragment antibody; NTF); Rhomboid-related protein 2 antibody; C-terminal fragment antibody; CTF)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rhomboid-related protein 2 protein (12-132AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RHBDL2 Antibody (CSB-PA019672LA01HU)，的标记方式是Non-conjugated。对于RHBDL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019672LB01HU RHBDL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA019672LC01HU RHBDL2 Antibody, FITC conjugated
    Biotin CSB-PA019672LD01HU RHBDL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.
  • 基因功能参考文献：
    1. Thrombomodulin and RHBDL2 are upregulated in human HaCaT cells stimulated by scratch wounds; furthermore, increased solulbe thrombomodulin was found in culture medium. PMID: 21833011
    2. RHBDL2 cleaves epidermal growth factor just outside its transmembrane domain, thereby facilitating its secretion and triggering activation of the epidermal growth factor receptor. PMID: 21494248
    3. Substrate specificity of RHBDL2 intramembrane protease is governed by helix-breaking residues in the transmembrane domain. PMID: 12820957
    4. Here, the s show that RHBDL2 is produced as a proenzyme and that the processing of RHBDL2 is required for its cellular protease activity. PMID: 19850051
    5. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. PMID: 15047175

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  • 亚细胞定位：
    [Rhomboid-related protein 2, C-terminal fragment]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peptidase S54 family
  • 数据库链接：

    HGNC: 16083

    OMIM: 608962

    KEGG: hsa:54933

    STRING: 9606.ENSP00000289248

    UniGene: Hs.524626