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RGS20 Antibody

  • 货号：
    CSB-PA019652GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O76081
  • 基因名：
    RGS20
  • 别名：
    G(z)GAP antibody; Gz selective GTPase activating protein antibody; Gz-GAP antibody; Gz-selective GTPase-activating protein antibody; HGNC:14600 antibody; Regulator of G protein signaling 20 antibody; Regulator of G-protein signaling 20 antibody; Regulator of G-protein signaling Z1 antibody; Regulator of Gz selective protein signaling 1 antibody; Regulator of Gz-selective protein signaling 1 antibody; RGS20 antibody; RGS20_HUMAN antibody; RGSZ1 antibody; ZGAP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RGS20
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
  • 基因功能参考文献：
    1. NEAT1 silencing also inhibited tumor growth in vivo. Collectively, we revealed that the NEAT1/miR365/RGS20 axis may be a novel mechanism or therapeutic strategy for OSCC treatment. PMID: 29484420
    2. Data suggest that Gpr176 (G-protein coupled receptor 176) is an SCN-(suprachiasmatic nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that sets the pace of circadian behavior; a unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176. [REVIEW] PMID: 28502923
    3. These results suggest that the expression of RGS20 may promote metastasis of tumor cells. PMID: 27495875
    4. Findings suggest that high regulator of G protein signaling 20 (RGS20) expression is associated with unfavorable survival in triple-negative breast cancer (TNBC). PMID: 28237701
    5. provide new evidence that RGSZ1 interacts not only with Galpha(z,) but also with Galpha(i), as supported by in vitro binding assays and functional studies PMID: 12379657
    6. NMR study PMID: 14872136
    7. The major function of PKCI-1 is to modulate mu opioid receptor signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction. PMID: 17126529

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  • 亚细胞定位：
    Membrane; Lipid-anchor. Nucleus. Cytoplasm.
  • 组织特异性：
    Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.
  • 数据库链接：

    HGNC: 14600

    OMIM: 607193

    KEGG: hsa:8601

    STRING: 9606.ENSP00000297313

    UniGene: Hs.368733