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RGS19 Antibody

  • 货号：
    CSB-PA019650LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA019650LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA019650LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA019650LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RGS19 Polyclonal antibody
  • Uniprot No.：
    P49795
  • 基因名：
    RGS19
  • 别名：
    G alpha interacting protein antibody; G protein signalling regulator 19 antibody; G protein; alpha-interacting protein antibody; G-alpha-interacting protein antibody; GAIP antibody; GNAI3IP antibody; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein antibody; Regulator of G protein signalling 19 antibody; Regulator of G-protein signaling 19 antibody; RGS19 antibody; RGS19_HUMAN antibody; RGSGAIP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RGS19 Antibody (CSB-PA019650LA01HU)，的标记方式是Non-conjugated。对于RGS19 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019650LB01HU RGS19 Antibody, HRP conjugated ELISA
    FITC CSB-PA019650LC01HU RGS19 Antibody, FITC conjugated
    Biotin CSB-PA019650LD01HU RGS19 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
  • 基因功能参考文献：
    1. RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal. PMID: 26116529
    2. RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect. PMID: 24793302
    3. Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity. PMID: 23799031
    4. The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23. PMID: 23416464
    5. elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases PMID: 22045062
    6. cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced PMID: 21705135
    7. gene structure and transcription regulation PMID: 12507475
    8. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling PMID: 15356268

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  • 亚细胞定位：
    Membrane; Lipid-anchor.
  • 组织特异性：
    Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
  • 数据库链接：

    HGNC: 13735

    OMIM: 605071

    KEGG: hsa:10287

    STRING: 9606.ENSP00000333194

    UniGene: Hs.422336