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RGS10 Antibody

  • 货号：
    CSB-PA003969
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using RGS10 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O43665
  • 基因名：
    RGS10
  • 别名：
    Regulator of G protein signaling 10 antibody; Regulator of G-protein signaling 10 antibody; RGS10 antibody; RGS10_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RGS10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.
  • 基因功能参考文献：
    1. RGS10 plays a role in chemoresistance in ovarian cancer. Loss of RGS10 enhances survival among these cells. PMID: 26293348
    2. RGS10 could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP from Rheb in ovarian cancer cells. PMID: 26319900
    3. Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance. PMID: 24475290
    4. RGS10 is a key molecule that contributes to the inhibition of Galpha-dependent signaling during chemokine-activated alpha4beta1- and alphaLbeta2-dependent T cell adhesion. PMID: 21705617
    5. RGS10 and RGS4 proteins are both detected in postmortem prefrontal cortex. PMID: 20816714
    6. Results establish RGS10 and RGS17 as novel regulators of cell survival and chemoresistance in ovarian cancer cells and suggest that their reduced expression may be diagnostic of chemoresistance. PMID: 21044322
    7. diffraction data were collected to 2.5 A resolution at 100 K using synchrotron radiation at Pohang beamline 4A PMID: 16511171
    8. Results demonstrate the specificity of RGS10A as a key component in the RANKL-evoked signaling pathway for osteoclast differentiation. PMID: 17881498

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm, cytosol. Nucleus.; Nucleus.
  • 数据库链接：

    HGNC: 9992

    OMIM: 602856

    KEGG: hsa:6001

    STRING: 9606.ENSP00000358099

    UniGene: Hs.501200