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RGS1 Antibody

  • 货号：
    CSB-PA274857
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from mouse muscle cells, using RGS1 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using RGS1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RGS1 Polyclonal antibody
  • Uniprot No.：
    Q08116
  • 基因名：
    RGS1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human RGS1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
  • 基因功能参考文献：
    1. Results showed that RGS1 expression was significantly higher in melanoma than that noted in nevus tissue and correlated with reduced diseasespecific survival. Also, RGS1 expression was also found to be related to the proliferation and migration of melanoma cells through regulation of Galphasmediated inactivation of AKT and ERK. PMID: 29620236
    2. The rs12022418 in RGS1 showed novel associations in IgA nephropathy. PMID: 27804980
    3. High RGS1 immunohistochemistry expression associates with poor overall survival in diffuse large B cell lymphoma PMID: 27775850
    4. RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new multiple myeloma therapy. PMID: 27445341
    5. Regulator of G-protein signaling 1 rs2816316 was negatively associated with celiac disease . PMID: 27043536
    6. RGS1 as a potential marker of CRC tissue quality PMID: 26222051
    7. RGS1 suppresses CXCL12-mediated migration and AKT activation in cultured human plasmacytoma cells and plasmablasts. PMID: 25897806
    8. Rgs1 has a role in leukocyte trafficking and vascular inflammation PMID: 25782711
    9. RGS1 and TNFRSF1A polymorphisms tended to be associated with reduced attack severity in Multiple sclerosis. PMID: 24130709
    10. RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies PMID: 23464602
    11. Markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders. PMID: 23324853
    12. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines PMID: 21795595
    13. RGS1 is a novel multiple sclerosis susceptibility loci, shared with celieac disease. PMID: 20555355
    14. Overexpression of RGS1 in progenitor pro-B cells (which have little endogenous RGS1) impairs CXCL12-induced focal adhesion kinase activation, chemotaxis, and adhesion to membrane domains. PMID: 15728464
    15. RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway. PMID: 16565322
    16. RGS1 is (over-) expressed in a broad variety of malignancies PMID: 18301890
    17. Results validate the role of RGS1 as a novel prognostic marker for melanoma given its impact on the survival associated with melanoma. PMID: 18580492
    18. Undifferentiated spondylarthritis (uSpA) peripheral blood mononuclear cells (PBMCs) carry more expressed genes than PBMCs from ankylosing spondylitis (AS) patients. TNFalpha- and IL-17-inducible RGS1 is a biomarker for uSpA, and to a lesser extent for AS. PMID: 19877080

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 组织特异性：
    Detected in peripheral blood monocytes. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
  • 数据库链接：

    HGNC: 9991

    OMIM: 600323

    KEGG: hsa:5996

    STRING: 9606.ENSP00000356429

    UniGene: Hs.75256