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RGN Antibody

  • 货号：
    CSB-PA623001LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat liver tissue, Mouse liver tissue
      All lanes: RGN antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 34, 25 kDa
      Observed band size: 34 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA623001LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA623001LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RGN Polyclonal antibody
  • Uniprot No.：
    Q15493
  • 基因名：
    RGN
  • 别名：
    Gluconolactonase antibody; GNL antibody; RC antibody; Regucalcin antibody; RGN antibody; RGN_HUMAN antibody; Senescence marker protein 30 antibody; SMP 30 antibody; SMP-30 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Regucalcin protein (1-299AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RGN Antibody (CSB-PA623001LA01HU)，的标记方式是Non-conjugated。对于RGN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA623001LB01HU RGN Antibody, HRP conjugated ELISA
    FITC CSB-PA623001LC01HU RGN Antibody, FITC conjugated
    Biotin CSB-PA623001LD01HU RGN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities.
  • 基因功能参考文献：
    1. Study suggests that regucalcin plays a crucial role as a suppressor in human colorectal cancer, and that the suppressed expression of the regucalcin gene may predispose patients to the promotion of colorectal cancer. PMID: 29956741
    2. The SMP30 may serve as a candidate of HCC clinical prognostic marker. PMID: 27991558
    3. Dat show that regucalcin (RGN) is lowly expressed in hepatocellular carcinoma (HCC) tissues and down-regulates the proliferation ability of HepG2 cells. PMID: 28028056
    4. These findings suggest that regucalcin may play a potential role as a suppressor of human lung cancer, and that downregulation of regucalcin expression may predispose patients to development of lung cancer. PMID: 28181135
    5. The role of RGN suppressing cell proliferation is associated with the regulation of expression of oncogenes and tumor suppressor genes. [review] PMID: 27411833
    6. High RGN expression is associated with hepatocellular carcinoma. PMID: 27633001
    7. the present study suggests that regucalcin may have important anticancer properties in human breast cancer patients. Mechanistically, these effects are likely mediated through suppression of multiple signaling pathways, upregulation of p53 and downregulation of oncogenes leading to anti-proliferative effects and reduced metastases to bone, a phenotype associated with poor clinical outcome. PMID: 27221776
    8. Study demonstrates that increased regucalcin gene expression greatly contributes to prolonged survival in human pancreatic cancer patients. Morover, overexpression of regucalcin was found to suppress the proliferation, which is enhanced through various signaling pathways. PMID: 26935290
    9. Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis. PMID: 26619319
    10. data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells. PMID: 25847529
    11. immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients PMID: 26072307
    12. results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa. PMID: 26171977
    13. This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review] PMID: 25230901
    14. The alternatively spliced variants of the regucalcin gene were found to be expressed in various human normal and tumor tissues. PMID: 25050833
    15. RGN overexpression protected from carcinogen-induced mammary gland tumor development and was linked with reduced proliferation and increased apoptosis. These findings indicated the protective role of RGN in the carcinogenesis of mammary gland. PMID: 25128811
    16. SMP30 can inhibit the proliferation and invasion of human hepatoma cells and thus can be regarded as a cancer suppressive factor. PMID: 24606440
    17. Overexpression of prostate RGN transgene in the prostate inhibits cell proliferation and apoptotic pathways. PMID: 24975685
    18. Regucalcin may be a key molecule in lipid metabolic disorder and diabetes--{review} PMID: 23453039
    19. structural feature of mouse SMP30/GNL seems to facilitate the gamma-lactone-ring formation PMID: 23349732
    20. Regucalcin may play a pivotal role in the regulation of Ca(2+) signaling which is stimulated through a neurotransmitter in the brain neurons with aging PMID: 22652898
    21. RGN has a role in spermatogenesis, directly or as a mediator of androgen action. [review] PMID: 22121208
    22. existence of multiple forms of SMP30 PMID: 21347421
    23. Rgn is a novel androgen-target gene in testis and may have a role in male reproductive function, particularly in the control of spermatogenesis. PMID: 21680783
    24. Studies indicate that regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function. PMID: 21431902
    25. Data show that regucalcin (RGN) reduces agonist (histamine)-induced Ca(2+) transients in RGN(+) transfected COS-7 cells (RGN(+)) and also increases their Ca(2+) storage capacity. PMID: 21684279
    26. SMP30 may be useful for hepatocellular carcinoma serologic screening, especially for the patients that are alpha-fetaprotein negative. PMID: 21047503
    27. These results suggest that hepatic SMP30 is closely associated with the pathogenesis of nonalcoholic fatty liver disease, although it is not known whether decreased hepatic SMP30 is a result or a cause of cirrhosis PMID: 19946731
    28. over-expression of SMP30/GNL in Hep G2 cells contributed to a decrease of reactive oxygen species formation accompanied by decreases of lipid peroxidation, superoxide dismutase activity and glutathione levels PMID: 19801822
    29. a domain of the SMP30 sequence 51 amino acid residues long was 60-66% similar to bacterial and yeast RNA polymerases PMID: 12619687
    30. SMP30 acts as a survival factor in hepatocytes PMID: 15358188
    31. crystal structure of regucalcin PMID: 15502314
    32. SMP30 induces formation of microvilli and bile canaliculi in HepG2 cells. PMID: 15714273
    33. regucalcin plays an important role as a suppressor in the enhancement of cell proliferation PMID: 15962315
    34. SMP30 also plays a very important role in a self-protective mechanism in survival and participates in the pathophysiological processes of acute liver failure. PMID: 18507831
    35. effect of sex steroid hormones on regucalcin expression in breast and prostate cancer cells suggest that it may be associated with development and progression of these human tumors PMID: 19347872
    36. Data suggest that through regucalcin and L-gulonolactone oxidase expression, beta-catenin regulates vitamin C biosynthesis in liver. PMID: 19690176

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    SMP-30/CGR1 family
  • 数据库链接：

    HGNC: 9989

    OMIM: 300212

    KEGG: hsa:9104

    STRING: 9606.ENSP00000253303

    UniGene: Hs.77854