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  4. RFX5 Antibody

RFX5 Antibody

  • 货号：
    CSB-PA019614GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P48382
  • 基因名：
  • 别名：
    DNA binding protein RFX 5 antibody; DNA binding protein RFX5 antibody; DNA-binding protein RFX5 antibody; Influences HLA class II expression antibody; Regulatory factor X 5 antibody; Regulatory factor X subunit 5 antibody; Regulatory factor X; 5 (influences HLA class II expression) antibody; RFX 5 antibody; RFX5 antibody; Rfx5 protein antibody; RFX5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human RFX5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
  • 基因功能参考文献：
    1. RFX5 acts as a direct positive transcriptional regulator of TPP1 in hepatocellular carcinoma. PMID: 27840983
    2. Data show arginine methyltransferase PRMT6 methylates the AT-hook motif of regulatory factor RFX5 and downregulates HLA-DQ expression. PMID: 23911394
    3. these data have identified as novel pathway whereby SIRT1 maintains COL1A2 synthesis in SMCs by modulating RFX5 activity. PMID: 23079621
    4. RFXAP(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5(N)(2) staple. PMID: 20732328
    5. interaction at COL1A2 start site and transcription repression PMID: 11986307
    6. The mutation for the fifth Bbare lymphocyte syndrome complementation group was found in RFX5 and was mapped to one of the arginines in a DNA-binding surface of this protein. Its wild-type counterpart restored function. PMID: 12368908
    7. RFX5 binds to the collagen transcription start site and represses collagen gene expression PMID: 12968017
    8. The identification of nuclear import and export sites on RFX molecules provides potential targets to modulate MHC class II expression. PMID: 15210800
    9. RFXAP and RFXB have roles in relieving autoinhibition of RFX5 PMID: 18723135
    10. TSA treatment enhances the association of CIITA with the transcription factor RFX5, which ameliorates the down-regulation of CIITA recruitment to target promoters by HDAC2. PMID: 19041327

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  • 相关疾病：
    Bare lymphocyte syndrome 2 (BLS2)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RFX family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 9986

    OMIM: 209920

    KEGG: hsa:5993

    STRING: 9606.ENSP00000290524

    UniGene: Hs.632472