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RFX3 Antibody

  • 货号：
    CSB-PA003966
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of RAW264.7 cells using RFX3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P48380
  • 基因名：
    RFX3
  • 别名：
    bA32F11.1 antibody; DNA binding protein RFX3 antibody; Regulatory factor X 3 antibody; Regulatory factor X; 3 (influences HLA class II expression) antibody; RFX3 antibody; RFX3_HUMAN antibody; Transcription factor RFX3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human RFX3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.
  • 基因功能参考文献：
    1. RFX3 interacts with the D sequence of adeno-associated virus inverted terminal repeat and regulates AAV transduction. PMID: 29317724
    2. findings reveal a regulation of RFX3 transcription factor and link fatty acid metabolism and protein lipidation to the regulation of ciliogenesis. PMID: 30127002
    3. FOXJ1 is an important regulator of cilia gene expression during ciliated cell differentiation, with RFX3 as a transcriptional co-activator to FOXJ1. PMID: 23822649
    4. RFX3 controls the expression of genes involved in primary ciliary dyskinesia. PMID: 19671664
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RFX family
  • 数据库链接：

    HGNC: 9984

    OMIM: 601337

    KEGG: hsa:5991

    STRING: 9606.ENSP00000371434

    UniGene: Hs.136829