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RD3 Antibody

  • 货号：
    CSB-PA800101LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RD3 antibody at 0.5µg/ml
      Lane 1: Mouse thymus tissue
      Lane 2: Human placenta tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 23 kDa
      Observed band size: 23 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA800101LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RD3 Polyclonal antibody
  • Uniprot No.：
    Q7Z3Z2
  • 基因名：
    RD3
  • 别名：
    RD3 antibody; C1orf36 antibody; Protein RD3 antibody; Retinal degeneration protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein RD3 protein (1-195AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RD3 Antibody (CSB-PA800101LA01HU)，的标记方式是Non-conjugated。对于RD3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA800101LB01HU RD3 Antibody, HRP conjugated ELISA
    FITC CSB-PA800101LC01HU RD3 Antibody, FITC conjugated
    Biotin CSB-PA800101LD01HU RD3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.
  • 基因功能参考文献：
    1. Re-expressing RD3 in metastatic site-derived aggressive cells reverted their metastatic potential both in vitro and in vivo. Conversely muting RD3 in neuroblastoma cells not only heightened invasion/migration but also dictated aggressive disease with metastasis. PMID: 26375249
    2. This study reports the results of an international study aimed at delineating the clinical and molecular spectrum of RD3 mutations in retinal dystrophies. PMID: 23308101
    3. Mutations in RD3 are a very rare cause of Leber's congenital amaurosis (LCA) associated with an extremely severe form of retinal dystrophy. PMID: 22531706
    4. RD3 suppresses the basal catalytic activity of guanylyl cyclase activating proteins (GCAP) in a noncompetitive manner. PMID: 21928830
    5. Identification and sequence analysis of C1orf36. PMID: 12914764
    6. the retinopathy-associated RD3 protein is part of subnuclear protein complexes involved in diverse processes, such as transcription and splicing. PMID: 17186464

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  • 相关疾病：
    Leber congenital amaurosis 12 (LCA12)
  • 亚细胞定位：
    Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed in retina. Widely expressed (at protein level). In the retina the strongest immunoreactivity is detected in the inner half of the cytoplasmic portion of the photoreceptor layer, where rods and cones are found, and the external half of the outer
  • 数据库链接：

    HGNC: 19689

    OMIM: 180040

    KEGG: hsa:343035

    STRING: 9606.ENSP00000355969

    UniGene: Hs.632495