RCN3 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) RCN3 Polyclonal antibody
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Uniprot No.:Q96D15
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基因名:RCN3
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别名:EF-hand calcium-binding protein RLP49 antibody; RCN3 antibody; RCN3_HUMAN antibody; reticulocalbin 3, EF-hand calcium binding domain antibody; Reticulocalbin-3 antibody; RLP49 antibody; UNQ239/PRO272 antibody
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宿主:Rabbit
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反应种属:Human, Mouse
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免疫原:Recombinant Human Reticulocalbin-3 protein (71-161AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,RCN3 Antibody (CSB-PA856914LA01HU),的标记方式是Non-conjugated。对于RCN3 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:200-1:500 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III...显示更多
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基因功能参考文献:
- genome-wide association study in US: Data suggest, among white subjects, an SNP in RCN3 (rs34459162) and a missense mutation in GCKR (rs1260236) are associated with serum levels of glycated albumin; among black subjects, an intergenic SNP in PRKCA (rs2438321) is associated with fructosamine levels and intronic variant in PRKCA (rs59443763) is associated with glycated albumin levels. (GCKR = glucokinase regulatory protein) PMID: 29844224
- RCN3 expression in systemic sclerosis was not statistically significantly different to healthy controls. PMID: 27468573
- Autoactivation & secretion of rat PACE4 was increased upon co-expression with recombinant human RCN-3. Selective and transient association of RCN-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4. PMID: 16433634
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亚细胞定位:Endoplasmic reticulum lumen.
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蛋白家族:CREC family
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组织特异性:Widely expressed.
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数据库链接:
HGNC: 21145
KEGG: hsa:57333
UniGene: Hs.567550