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RBP3 Antibody

  • 货号：
    CSB-PA019482GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P10745
  • 基因名：
    RBP3
  • 别名：
    D10S64 antibody; D10S65 antibody; D10S66 antibody; Interphotoreceptor retinoid binding protein antibody; Interphotoreceptor retinoid-binding protein antibody; Interstitial retinol binding protein antibody; Interstitial retinol-binding protein antibody; IRBP antibody; RBP 3 antibody; rbp3 antibody; RBPI antibody; RET3_HUMAN antibody; Retinol binding protein 3 antibody; Retinol binding protein 3 interstitial antibody; Retinol-binding protein 3 antibody; RP66 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RBP3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
  • 基因功能参考文献：
    1. this report is the first to describe the retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the requirement for IRBP in normal eye development and visual function. PMID: 25766589
    2. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
    3. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. PMID: 23882694
    4. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). PMID: 23486466
    5. The mouse retina promotes cone dark adaptation eightfold faster than the retinal pigment epithelium. However, complete cone recovery requires both visual cycles. PMID: 21613504
    6. Underproduction of IRBP is an early event in the human diabetic retina and is associated with retinal neurodegeneration. PMID: 19823802
    7. studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5 PMID: 15713799
    8. analysis of IRBP proteolysis is useful as a biomarker for uveitis PMID: 18266969
    9. Mutations in RBP3 are an infrequent cause of autosomal recessive retinitis pigmentosa. PMID: 19074801
    10. In interphotoreceptor retinoid-binding protein transgenic mice cone dysfunction appears to be caused by abnormal trafficking of cone opsins due to impaired delivery of all-transretinaldehyde chromophore without IRBP. PMID: 19193895

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  • 相关疾病：
    Retinitis pigmentosa 66 (RP66)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
  • 蛋白家族：
    Peptidase S41A family
  • 数据库链接：

    HGNC: 9921

    OMIM: 180290

    KEGG: hsa:5949

    STRING: 9606.ENSP00000224600

    UniGene: Hs.591928