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RBP1 Antibody

  • 货号：
    CSB-PA019480YA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019480YA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RBP1 Polyclonal antibody
  • Uniprot No.：
    P09455
  • 基因名：
    RBP1
  • 别名：
    Cellular retinol binding protein antibody; Cellular retinol-binding protein antibody; Cellular retinol-binding protein I antibody; CRABP I antibody; CRBP antibody; CRBP-I antibody; CRBP1 antibody; CRBPI antibody; RBP 1 antibody; RBP1 antibody; RBPC antibody; RET1_HUMAN antibody; Retinol binding protein 1 cellular antibody; Retinol-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Retinol-binding protein 1 protein (70-112AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RBP1 Antibody (CSB-PA019480YA01HU)，的标记方式是Non-conjugated。对于RBP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019480YB01HU RBP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA019480YC01HU RBP1 Antibody, FITC conjugated
    Biotin CSB-PA019480YD01HU RBP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.
  • 基因功能参考文献：
    1. Low CRBP1 expression is associated with low radiation sensitivity in rectal cancer. PMID: 28291773
    2. This conformational flexibility of human apo-CRBP1 facilitates interaction with the ligands, whereas the more rigid holoprotein structure protects the labile retinoid moiety during vitamin A transport. PMID: 26900151
    3. Hypermethylation of CRBP1 gene is associated with Epstein-Barr virus-associated gastric carcinomas. PMID: 25720522
    4. Further studies are needed to explore new therapeutic strategies aimed at restoring CRBP-1-mediated intracellular retinol trafficking and the meaning of CRBP-1 expression in cancer patients screening for a more personalized and efficacy retinoid therapy PMID: 25879031
    5. RBP1 expression was reduced in tissue and endometrial stromal cells derived from endometritis lesions versus eutopic endometruim in humans and mice. PMID: 25143356
    6. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1, that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis. PMID: 23890161
    7. Factors involved in the retinoid pathway, in particular upregulation of CRBP, CRABP1 and CRABP2, also showed differential expression in tumors with different histological subtypes PMID: 24269351
    8. CRBP-1 loss in G2/G3 ovarian carcinomas and increased apoptotic susceptibility to retinoids. PMID: 24982334
    9. Suggest CRBP1 gene as a tumor suppressor gene for cervical cancer. PMID: 24040446
    10. High urine retinol binding protein is associated with interstitial fibrosis and tubular atrophy plus inflammation. PMID: 23414180
    11. RBP1 promoter hypermethylation is found in nearly all IDH1 and IDH2 mutant gliomas Because RBP1 is involved in retinoic acid synthesis, results suggest that dysregltion of RA metabolism may contribute to glioma formation along the IDH1/IDH2-mutant pathway PMID: 22945948
    12. CRBP-1 plays a role in ventricular remodeling after myocardial infarction allegedly through its RA binding activity. PMID: 22449228
    13. Increased expression and unmethylated promoter of the CRBP1 gene could be considered as markers for larynx cancer. PMID: 22049223
    14. Data show that CRBPI and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal. PMID: 21382444
    15. STRA6 not only is a vitamin A transporter but also is a cell-surface signaling receptor activated by the RBP-retinol complex. PMID: 21368206
    16. CRBP1 gene could have a tumor suppressive function in bladder cancer. PMID: 21042705
    17. It is likely that mutations in RGR, RBP3, and possibly RBP1 occur rarely in inherited retinal dystrophies. PMID: 21067480
    18. protein-ligand interaction differences between CRBP-I and CRBP-II PMID: 19965581
    19. a high CRBP-1 expression is associated with smooth muscle malignancy and suggest that CRBP-1 expression represents a new useful marker for the classification of unusual variants of smooth muscle tumors PMID: 12111198
    20. CRBP1 has a role in vitamin A metabolism and its absence may play a role in ovarian cancer oncogenesis PMID: 12631600
    21. may serve as a surrogate marker for graft dysfunction early after kidney transplantation PMID: 12826154
    22. in liver cancer modulation of CRBP-1 expression in HCCs contributes to tumor growth and progression via retinoid-mediated signaling and disruption of cellular vitamin A homeostasis. PMID: 12883492
    23. Colocalization of plasma retinol-binding protein with RPE65 and affinity binding suggest a direct interaction of RPE65 with plasma retinol-binding protein in cultured human keratinocytes that might be involved in retinoid uptake of keratinocytes. PMID: 15009723
    24. in fibrotic or cirrhotic liver, the different patterns of expression for CRBP-1 and alpha-SMA allow the distinction of different subsets of fibroblastic cells involved in fibrogenesis and septa formation PMID: 15094224
    25. CRBP-I downregulation in cancer promotes tumor progression through inhibition of retinoic acid receptor activity and derepression of PI3K/Akt signaling via a novel mechanism. PMID: 15608670
    26. The widely expressed CRBP1, which binds all-trans-retinol with much higher affinity than all-trans-retinaldehyde, restricts the oxidation of all-trans-retinol by retinol dehydrogenase 12 but has little effect on the reduction of all-trans-retinaldehyde. PMID: 15865448
    27. CRBP-1+ cells increased in squamous intraepithelial lesions and slightly decreased in invasive squamous cell carcinomas. PMID: 17593084
    28. Retinoic acid and retinol regulate expression of cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells. PMID: 18343808
    29. CRBP-1 clearly stains liver lobular HSCs without reacting with smooth muscle cells (SMCs) and shows variable cholangiocyte p PMID: 19052772
    30. Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma. PMID: 19288010

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  • 亚细胞定位：
    Cytoplasm. Lipid droplet.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 组织特异性：
    Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver.
  • 数据库链接：

    HGNC: 9919

    OMIM: 180260

    KEGG: hsa:5947

    STRING: 9606.ENSP00000232219

    UniGene: Hs.529571