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RBMX Antibody

  • 货号：
    CSB-PA002947
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using hnRNP G Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P38159
  • 基因名：
    RBMX
  • 别名：
    RBMX antibody; HNRPG antibody; RBMXP1 antibody; RNA-binding motif protein antibody; X chromosome antibody; Glycoprotein p43 antibody; Heterogeneous nuclear ribonucleoprotein G antibody; hnRNP G) [Cleaved into: RNA-binding motif protein antibody; X chromosome antibody; N-terminally processed] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human hnRNP G.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
  • 基因功能参考文献：
    1. These results suggest that satellite I RNA plays a role in stabilizing RBMX and Sororin in the ncRNP complex to maintain proper sister chromatid cohesion. PMID: 29383807
    2. HNRNPG binds m6A-methylated RNAs through its C-terminal low-complexity region, which self-assembles into large particles in vitro. The Arg-Gly-Gly repeats within the low-complexity region are required for binding to the RNA motif exposed by m6A methylation. PMID: 28334903
    3. A sequence deletion within RBMX is identified as associated with with Shashi X-linked intellectual disability syndrome. PMID: 25256757
    4. Host RBMX is required for the maintenance of Borna disease virus nuclear viral factories. PMID: 26333388
    5. Results showed that HNRNPG and HTRA2-BETA1 were specific antagonistic regulators of ERa exon7 splicing and increased HNRNPG levels were associated with improved clinical outcome of endometrial cancer through up-regulation of ERaD7 expression. PMID: 25884434
    6. RBMX is a cohesion regulator that maintains the proper cohesion of sister chromatids. PMID: 22832223
    7. Data show that RBMX accumulated at DNA lesions through multiple domains in a poly(ADP-ribose) polymerase 1-dependent manner and promoted HR by facilitating proper BRCA2 expression. PMID: 22344029
    8. studied the genetic and expression states of hnRNP G in normal, premalignant and malignant human oral tissues to further understand the relationship between the hnRNP G alterations and the development of human oral cancer PMID: 21840245
    9. evidence provided that deletions in or around RBMX may be involved in non-obstructive azoospermia(NOA) PMID: 16491274
    10. From these results, it seems that the X-chromosome, through its RBM genes, plays a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer. PMID: 16552754
    11. p53 modulates DNA DSB repair by, in part, inducing hnRNP G PMID: 17387044
    12. This identifies RBMX as an ARTS-1-associated protein that regulates both the constitutive release of TNFR1 exosome-like vesicles and the inducible proteolytic cleavage of TNFR1 ectodomains. PMID: 18445477

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  • 相关疾病：
    Mental retardation, X-linked, syndromic, 11 (MRXS11)
  • 亚细胞定位：
    Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.
  • 组织特异性：
    Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level).
  • 数据库链接：

    HGNC: 9910

    OMIM: 300199

    KEGG: hsa:27316

    STRING: 9606.ENSP00000359645

    UniGene: Hs.380118