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RBL1 Antibody

  • 货号：
    CSB-PA019398GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P28749
  • 基因名：
  • 别名：
    107 kDa retinoblastoma-associated protein antibody; Cellular protein 107 antibody; Cellular protein p107 antibody; CP107 antibody; MGC40006 antibody; p107 antibody; PRB1 antibody; RBL1 antibody; RBL1_HUMAN antibody; Retinoblastoma like protein 1 antibody; retinoblastoma-like 1 (p107) antibody; Retinoblastoma-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RBL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. Study found that the methylation of global DNA decreased gradually after irradiation, and the methylation of the promoter of RBL1 gene may play an important role in the induction of radioresistance for three dimensional cultured carcinoma cells. PMID: 27779109
    2. These findings in human skeletal muscle suggest that attenuated transcriptional repression through p107 may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise. PMID: 28270591
    3. The s found that phosphorylation of residues S650 and S975 in p107 weakens the E2F4 transactivation domain binding. PMID: 27567532
    4. UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins PMID: 28289097
    5. Sequence analysis of the RB1 gene detected a novel mutation in bilateral retinoblastoma. PMID: 22729126
    6. MAGE-A11 is a proto-oncogene whose increased expression in prostate cancer reverses retinoblastoma-related protein p107 from a transcriptional repressor to a transcriptional activator of the androgen receptor and E2F1. PMID: 23853093
    7. Single nucleotide polymorphism in the ultraconserved elements of RBL1 gene is associated with recurrence in colorectal adenocarcinoma. PMID: 22673945
    8. Concomitant germline large cytogenetic 13q deletion and somatic mutations in the RB1 gene in unilateral retinoblastoma. PMID: 22303805
    9. may have a role in the mechanisms of proliferation and differentiation during human placental development PMID: 11642725
    10. regulation of expression of p130, p107 and E2F-4 in human cells PMID: 12006580
    11. suggests that the p107 N-terminus provides an interaction domain for transcription factors involved in cell cycle control PMID: 12439743
    12. report shows hypophosphorylation of the retinoblastoma family proteins induced by H2O2 was because of the activity of protein phosphatase 2A PMID: 12621062
    13. p107 plays a constitutive role in the progression of papillary carcinoma of the thyroid and that decreased p107 expression may contribute to the transformation from follicular adenoma to follicular carcinoma and anaplastic transformation. PMID: 14666683
    14. Induction of p130 and p107 play an important role in the inhibition of growth of C33A cells by MIS. PMID: 14671316
    15. the PP2A catalytic subunit (PP2A/C) specifically interacts with both p130 and p107 in quiescent cells as well as cells progressing throughout the cell cycle PMID: 15467457
    16. Data suggest that p107, in addition to its interaction with E2F, inhibits cell proliferation through the control of Skp2 expression and the resulting stabilization of p27. PMID: 15631990
    17. p107 is a trancriptional regulator of the cell cycle genes. PMID: 16135806
    18. These results demonstrate a mechanistic role for p130 and compensatory roles for p107 and RB in the long-term senescence-like growth arrest response of breast cancer cells to DNA damage. PMID: 16537896
    19. The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750
    20. Differentiating human adipose-derived human stem cells (hASC), do not undergo clonal expansion and p130 expression gradually diminishes across differentiation. However, p107 expression is transiently increased during hASC differentiation. PMID: 18086563
    21. P107 is needed for initiation of accelerated cellular senescence in the absence of Rb and introduces the concept that p130 may be required to prevent the onset of terminal growth arrest in unstimulated prostate cancer cells lacking a functional Rb allele. PMID: 18418057
    22. These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex. PMID: 18799622

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Retinoblastoma protein (RB) family
  • 数据库链接：

    HGNC: 9893

    OMIM: 116957

    KEGG: hsa:5933

    STRING: 9606.ENSP00000362768

    UniGene: Hs.207745