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RASSF8 Antibody

  • 中文名称：
    RASSF8兔多克隆抗体
  • 货号：
    CSB-PA004748
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of rat stomach cells using RASSF8 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8NHQ8
  • 基因名：
    RASSF8
  • 别名：
    C12orf2 antibody; Carcinoma associated HOJ 1 antibody; Carcinoma associated protein HOJ 1 antibody; Carcinoma-associated protein HOJ-1 antibody; HoJ 1 antibody; HoJ1 antibody; Ras association (RalGDS/AF 6) domain family (N terminal) member 8 antibody; Ras association (RalGDS/AF 6) domain family 8 antibody; Ras association domain containing protein 8 antibody; Ras association domain family 8 antibody; Ras association domain-containing protein 8 antibody; RASF8_HUMAN antibody; RASSF 8 antibody; Rassf8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RASSF8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. data provide evidence that E4BP4 attenuates RASSF8-mediated anti-proliferation and apoptosis, shedding mechanistic insights into RASSF8 down-regulation in breast cancers. PMID: 29467226
    2. MiR-505 mediated MTX resistance, propagation, cell cycle and metastasis by targeting RASSF8 in colorectal cancer PMID: 29726011
    3. The miR-224 played an oncogenic role in the proliferation of NSCLC by direct targeting RASSF8. PMID: 28770961
    4. RASSF8 knockdown by specific RNAi showed similar effects in cervical cancer cells transfected with miR-224 mimic. Our findings suggest that miR-224 directly targets RASSF8 and thereby acts as a tumor promoter in cervical cancer progression PMID: 27626930
    5. These results indicate that hypoxia-inducible miR-224 promotes gastric cancer cell growth, migration and invasion by downregulating RASSF8 and acts as an oncogene, implying that inhibition of miR-224 may have potential as a therapeutic target for patients with hypoxic gastric tumors. PMID: 28173803
    6. RASSF8 acts as a tumor suppressor in squamous cell carcinoma PMID: 26439687
    7. RASSF8 plays a significant role in suppressing the progression of cutaneous melanoma. PMID: 26334503
    8. RASSF8 as a tumor suppressor gene that is essential for maintaining AJs function in epithelial cells and have a role in epithelial cell migration. PMID: 20514026
    9. Expression of RASSF8 protein by transfected lung cancer cells led to inhibition of anchorage-independent growth in soft agar in A549 cells and reduction of clonogenic activity in NCI-H520 cells PMID: 16462760

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  • 相关疾病：
    A chromosomal aberration involving RASSF8 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with FBLN1.
  • 组织特异性：
    Widely expressed as a 6.2 kb transcript. A 2.2 kb alternatively spliced transcript is expressed exclusively in testis.
  • 数据库链接：

    HGNC: 13232

    OMIM: 608180

    KEGG: hsa:11228

    STRING: 9606.ENSP00000282884

    UniGene: Hs.696433