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RASGRP3 Antibody

  • 货号：
    CSB-PA808539ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RASGRP3 Polyclonal antibody
  • Uniprot No.：
    Q8IV61
  • 基因名：
  • 别名：
    Calcium and DAG-regulated guanine nucleotide exchange factor III antibody; Grp3 antibody; GRP3_HUMAN antibody; Guanine nucleotide exchange factor for Rap1 antibody; Kiaa0846 antibody; RAS guanyl releasing protein 3 (calcium and DAG regulated) antibody; RAS guanyl releasing protein 3 calcium and DAG regualated guanine nucleotide exchange factor iii antibody; Ras guanyl-releasing protein 3 antibody; RASGRP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ras guanyl-releasing protein 3 protein (541-690AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
  • 基因功能参考文献：
    1. In conclusion, these findings provide a new insight into the upregulation of RasGRP3 involved in Notch pathway activation in the development of esophageal squamous cell carcinoma , especially under nutrient deprivation. PMID: 29048643
    2. these data show that RasGRP3 exerts its oncogenic effect in papillary thyroid cancer through Akt-mediated MDM2 activation. PMID: 28864115
    3. RasGRP3 mediates ERK MAPK pathway activation in GNAQ mutant uveal melanoma. PMID: 28486107
    4. Knockdown of RasGRP3 inhibited proliferation in prostate neoplasms. PMID: 24418912
    5. Ras activator RasGRP3 may have a role in the pathological behavior of breast cancer cells and may constitute a therapeutic target for human breast cancer. PMID: 24779681
    6. The identification of the role of RasGRP3 in melanoma highlights its importance, as a Ras activator, in the phosphoinositide signaling pathway in human melanoma. PMID: 21602881
    7. Significant associations were found for the single nucleotide polymorphism rs13385731 of RasGRP3 with malar rash, discoid rash, and antinuclear antibody in patients with systemic lupus erythematosus PMID: 20516000
    8. RasGRP3 contributes to the malignant phenotype of prostate cancer cells and may constitute a novel therapeutic target for human prostate cancer. PMID: 20876802
    9. A vascular gene trap screen defines RASGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. PMID: 15572660
    10. studies support the hypothesis that RasGRP phosphorylation by PKC is a mechanism that integrates DAG signaling systems in T and B cells PMID: 15657177
    11. dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellular localization of the exchange factor PMID: 17012239

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  • 蛋白家族：
    RASGRP family
  • 数据库链接：

    HGNC: 14545

    OMIM: 609531

    KEGG: hsa:25780

    STRING: 9606.ENSP00000384192

    UniGene: Hs.143674