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RARS Antibody

  • 货号：
    CSB-PA019344GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P54136
  • 基因名：
    RARS
  • 别名：
    2610011N19Rik antibody; 2610037E21Rik antibody; AL033339 antibody; Arginine tRNA ligase 1, cytoplasmic antibody; Arginine tRNA ligase antibody; Arginine--tRNA ligase antibody; Arginyl tRNA synthetase 1 antibody; Arginyl tRNA synthetase cytoplasmic antibody; Arginyl tRNA synthetase, cytoplasmic antibody; Arginyl-tRNA synthetase, cytoplasmic antibody; ArgRS antibody; AW985894 antibody; DALRD 1 antibody; DALRD1 antibody; EC 6.1.1.19 antibody; MGC8641 antibody; MGC86730 antibody; RARS antibody; SYRC_HUMAN antibody; wu:fa96g09 antibody; zgc:56050 antibody; zgc:86730 antibody
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RARS
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.
  • 基因功能参考文献：
    1. Missense variant Ser456Leu and a de novo deletion Tyr616Leufs*6 cause disorder akin to Pelizaeus-Merzbacher disease. PMID: 28905880
    2. Data indicate that the N terminus of Pro-EMAP II binds to its C terminus, arginyl-tRNA synthetase, and the neurofilament light subunit. PMID: 25724651
    3. The mRNA of human cytoplasmic arginyl-tRNA synthetase recruits prokaryotic ribosomes independently. PMID: 24898251
    4. report describe 4 patients with hypomyelination and mutations in RARS PMID: 24777941
    5. The crystal structures of the L-arginine-complexed, and L-canavanine-complexed forms of arginyl-tRNA synthetase from Homo sapiens. PMID: 24859084
    6. Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity PMID: 20923763
    7. leucyl-tRNA synthetase requires its C-terminal domain for its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex PMID: 16055448
    8. RARS over-expression impairs aminoacyl t-RNA synthetase interacting multifunctional protein (AIMP1) secretion by both HeLa and MCF7 cells. PMID: 17443684

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  • 相关疾病：
    Leukodystrophy, hypomyelinating, 9 (HLD9)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 数据库链接：

    HGNC: 9870

    OMIM: 107820

    KEGG: hsa:5917

    STRING: 9606.ENSP00000231572

    UniGene: Hs.654907