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RAPGEF4 Antibody

  • 货号：
    CSB-PA820189ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA820189ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA820189ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAPGEF4 Polyclonal antibody
  • Uniprot No.：
    Q8WZA2
  • 基因名：
  • 别名：
    CAMP GEFII antibody; cAMP regulated guanine nucleotide exchange factor II antibody; cAMP-GEFII antibody; cAMP-regulated guanine nucleotide exchange factor II antibody; CAMPGEFII antibody; CGEF 2 antibody; CGEF2 antibody; Epac 2 antibody; EPAC2 antibody; Exchange factor directly activated by cAMP 2 antibody; Exchange protein directly activated by cAMP 2 antibody; Nbla00496 antibody; Putative protein product of Nbla00496 antibody; Rap guanine nucleotide exchange factor (GEF) 4 antibody; Rap guanine nucleotide exchange factor 4 antibody; RAPGEF 4 antibody; Rapgef4 antibody; RPGF4_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rap guanine nucleotide exchange factor 4 protein (1-210AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
  • 基因功能参考文献：
    1. Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production. PMID: 27649969
    2. rs17746510, one of the three single-nucleotide polymorphisms (SNPs) in RAPGEF4 associated with cognitive decline in Chinese Alzheimer's disease (AD) patients, was significantly correlated with apathy and mood disturbance PMID: 27598965
    3. Data show that Epac2 is activated by cAMP and changes its structure. It is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase and is expressed mainly in brain, neuroendocrine and endocrine tissues. [review] PMID: 26390815
    4. CALR regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF and PTGS2-mediated production of PGE2 through cAMP signaling. PMID: 25378661
    5. Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. PMID: 25187374
    6. EPAC2-mediated CRT expression is essential for the functional and morphological differentiation of endometrial stromal cells into decidual cells PMID: 24169561
    7. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry PMID: 21454623
    8. An important time-limited role is identified for hippocampal Epac2 signaling in cognition, opening new avenues to investigate the molecular mechanisms underlying memory retrieval. PMID: 19739231
    9. Epac2 & Epac1 signaling pathways may be associated with cAMP-mediated functional differentiation and syncytialization of trophoblasts. Expression of Epac2 & Epac 1 in placenta at different stages was investigated. PMID: 20663796
    10. Studies demonstrate the occurrence of the EPAC2 splicing variant EPAC2B in adrenocortical cancer cells and reveal the involvement of EPAC2B in cAMP-induced effects on cytoskeleton integrity and cell migration. PMID: 20233795
    11. Mutations in the hinge of Epac can uncouple cAMP binding from its exchange activity. PMID: 12469113
    12. variants were present in five families, where they segregate with the autistic phenotype. PMID: 14593429
    13. Epac2 signaling plays a stimulatory role in pancreatic and intestinal endocrine cells, including proglucagon transcription and glucagon and GLP-1 production. PMID: 18854429
    14. Substitution of the conserved phenylalanine 435 with glycine facilitates the hinge bending and leads to a constitutively active Epac2 capable of stimulating nucleotide exchange in the absence of cAMP. PMID: 19553663

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 组织特异性：
    Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
  • 数据库链接：

    HGNC: 16626

    OMIM: 606058

    KEGG: hsa:11069

    STRING: 9606.ENSP00000380271

    UniGene: Hs.470646