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RAP1GDS1 Antibody

  • 货号：
    CSB-PA019325GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P52306
  • 基因名：
  • 别名：
    Exchange factor smgGDS antibody; GDP dissociation stimulator 1 antibody; GDS1 antibody; GDS1_HUMAN antibody; GTP-GDP dissociation stimulator 1 antibody; GTPase-GDP dissociation stimulator; Rap1; 1 antibody; Highly similar to RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1 antibody; MGC118859 antibody; MGC118861 antibody; RAP1 antibody; Rap1 GTPase-GDP dissociation stimulator 1 antibody; RAP1GDS1 antibody; SMG GDS protein antibody; SMG P21 stimulatory GDP/GTP exchange protein antibody; SMGGDS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RAP1GDS1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake.
  • 基因功能参考文献：
    1. Study reveals a cryptic pocket by which SmgGDS-558 accommodates RhoA prenylation, loosening the structure of Rho when it interacts with SmgGDS, which may enable drug development strategies for targeting SmgGDS and small GTPases. PMID: 30190425
    2. a novel nuclear role for SmgGDS in protecting malignant cells from nucleolar stress, thus promoting cell cycle progression and tumorigenesis. PMID: 28806394
    3. Data suggest that SmgGDS-558 splice variant exhibits a fold containing tandem copies of armadillo-repeat motifs not present in other guanine nucleotide exchange factors (GEFs); SmgGDS harbors distinct positively and negatively charged regions, both of which play critical roles in binding to RhoA and in GEF activity. (SmgGDS = smg p21 stimulatory GDP exchange protein; RhoA = ras homolog gene family, member A) PMID: 28630045
    4. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1, played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF member. PMID: 27716788
    5. results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins PMID: 26598509
    6. DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS PMID: 26814130
    7. SmgGDS promotes cell cycle progression in multiple types of cancer, making SmgGDS a valuable target for cancer therapeutics. PMID: 24552806
    8. TG2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1. PMID: 24349085
    9. findings identify SmgGDS-558 as an activator of RhoA and NF-kB in breast cancer, and demonstrate a functional role for SmgGDS-558 in the proliferation of breast cancer cells and tumorigenesis. PMID: 24197117
    10. this study provides evidence that SmgGDS-607 associates with GTPases through recognition of the last amino acid in the CAAX motif. PMID: 24415755
    11. findings provide compelling evidence of a novel role for junctional adhesion molecule-A (JAM-A)in driving breast cancer cell migration via activation of Rap1 GTPase and beta1-integrin PMID: 21429211
    12. Results indicate that SmgGDS is a bona fide GEF that specifically activates RhoA and RhoC through a unique mechanism not used by other Rho family exchange factors. PMID: 21242305
    13. C3G stimulates guanine nucleotide exchange on Drosophila Rap GTPases in vitro PMID: 20209136
    14. ALK activation of Rap1 via the Rap1-specific GEF C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma. PMID: 20190816
    15. activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes PMID: 12690117
    16. results demonstrate that B-CLL cells uniquely activate Rap1 in response to PDE4 inhibitors and suggest that physiologic stimuli that activate EPAC may transmit an antiapoptotic signal PMID: 14615375
    17. SmgGDS promotes the malignant Non-small cell lung carcinoma (NSCLC)phenotype and is an intriguing therapeutic target in NSCLC. PMID: 17951244
    18. Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis. PMID: 19546222

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  • 亚细胞定位：
    Cytoplasm, cytosol. Endoplasmic reticulum. Mitochondrion.
  • 数据库链接：

    HGNC: 9859

    OMIM: 179502

    KEGG: hsa:5910

    STRING: 9606.ENSP00000340454

    UniGene: Hs.132858