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RANBP10 Antibody

  • 货号：
    CSB-PA019309GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6VN20
  • 基因名：
    RANBP10
  • 别名：
    FLJ31165 antibody; KIAA1464 antibody; RAN binding protein 10 antibody; Ran-binding protein 10 antibody; RanBP10 antibody; RBP10_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RANBP10
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.
  • 基因功能参考文献：
    1. s provide evidence that enhancement of neuronal morphology through RANBP10 is one of the neuroprotective mechanisms for miR-196a. PMID: 28744327
    2. The results showed that ICP0 interacted with cell protein RanBP10, a known transcriptional coactivator, in human herpesvirus 1-infected cells. PMID: 26739050
    3. data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma PMID: 20395553
    4. RanBP10 might serve as a molecular link between Ran and noncentrosomal microtubules PMID: 18347012
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic.
  • 蛋白家族：
    RANBP9/10 family
  • 组织特异性：
    Broadly expressed, with highest levels in skeletal muscle.
  • 数据库链接：

    HGNC: 29285

    OMIM: 614031

    KEGG: hsa:57610

    STRING: 9606.ENSP00000316589

    UniGene: Hs.368569