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RALB Antibody

  • 货号：
    CSB-PA219431
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA219431(RALB Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using CSB-PA219431(RALB Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse lung tissue, Primary antibody: CSB-PA219431(RALB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P11234
  • 基因名：
  • 别名：
    5730472O18Rik antibody; dRalb antibody; GTP binding protein antibody; Ralb antibody; RALB_HUMAN antibody; RAS like protein B antibody; RAS like proto oncogene B antibody; Ras related GTP binding protein B antibody; Ras-related protein Ral-B antibody; v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody; v ral simian leukemia viral oncogene homolog B (ras related) antibody; V ral simian leukemia viral oncogene homolog B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human RALB
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:500-1:5000
    WB 1:500-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors.
  • 基因功能参考文献：
    1. our work provides new insight into the specific roles of Ras effector pathways in acute myeloid leukemia and has identified RALB signaling as a key survival pathway PMID: 27556501
    2. High RALB expression is associated with acute myeloid leukemia. PMID: 27991934
    3. Inhibition of Ral GTPases Using a Stapled Peptide Approach. PMID: 27334922
    4. These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I. PMID: 25573158
    5. High RALB mRNA expression is associated with non-small-cell lung cancer growth and progression. PMID: 24389431
    6. Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance. PMID: 24747441
    7. nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles PMID: 24056301
    8. a novel RalB-mediated biochemical and signaling mechanism for invadopodium formation PMID: 22331470
    9. Study finds that the Ras-like small G protein, RalB, is localized to nascent autophagosomes and is activated on nutrient deprivation. PMID: 21241894
    10. Non-phosphorylated RalB is associated with bladder cancer cell growth and metastasis. PMID: 20940393
    11. RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival; RALB is specifically required for survival of tumour cells but not normal cells PMID: 12856001
    12. These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
    13. RalB was found to mediate SDF-1-induced migration PMID: 18227351
    14. Backbone dynamics and the structure of free RalB bound to the GTP analogue GMPPNP were determined using NMR spectroscopy. PMID: 19166349
    15. 1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation. Backbone amide dynamics parameters for a majority of residues have also been obtained PMID: 19636851

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 数据库链接：

    HGNC: 9840

    OMIM: 179551

    KEGG: hsa:5899

    STRING: 9606.ENSP00000272519

    UniGene: Hs.469820