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RABGEF1 Antibody

  • 货号：
    CSB-PA019233GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UJ41
  • 基因名：
    RABGEF1
  • 别名：
    RAB guanine nucleotide exchange factor (GEF) 1 antibody; Rab5 GDP/GTP exchange factor antibody; Rab5ef antibody; Rabaptin 5 associated exchange factor for Rab5 antibody; Rabaptin-5-associated exchange factor for Rab5 antibody; Rabex 5 antibody; Rabex-5 antibody; RABGEF 1 antibody; Rabgef1 antibody; RABX 5 antibody; RABX5 antibody; RABX5_HUMAN antibody; RAP1 antibody; Rin 2 antibody; Rin2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RABGEF1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
  • 基因功能参考文献：
    1. The s demonstrate that RABGEF1, the upstream factor of the endosomal Rab GTPase cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin. RABGEF1 directs the downstream Rab proteins, RAB5 and RAB7A, to damaged mitochondria, whose associations are further regulated by mitochondrial Rab-GAPs. PMID: 29360040
    2. RABEX-5 mRNA expression was significantly upregulated in colorectal cancer tissues. PMID: 28617553
    3. we identify Rabex-5 as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs. PMID: 27601648
    4. findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function PMID: 27820702
    5. The results contradict the model of feedback activation of Rab5 and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 to activate Rab5 in a feed-forward manner. PMID: 26430212
    6. RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients PMID: 26002576
    7. Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis. PMID: 25427001
    8. analysis of Rabex-5 GEF activation by Rabaptin-5 PMID: 24957337
    9. This implies that Rap regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated PMID: 24714377
    10. RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy. PMID: 24716822
    11. Interaction of Rabex-5 with Rab5 depends on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization. PMID: 23048039
    12. KCa2.3 is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin- and Rab5-dependent manner. PMID: 22952906
    13. a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation. PMID: 22846990
    14. RABEX-5 and RAB5 may be involved in the development of breast cancer metastasis. PMID: 21500550
    15. functions as an E3 ligase for Ras PMID: 20655225
    16. GGAs, a family of Arf-dependent clathrin adaptors involved in selection of TGN cargo, interact with the Rabaptin-5-Rabex-5 complex, a Rab4/Rab5 effector regulating endosome fusion PMID: 12505986
    17. Here, we report that Rabex-5, a guanine nucleotide exchange factor for Rab5, binds to ubiquitin through two independent ubiquitin binding domains PMID: 16499958
    18. Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity PMID: 17341663
    19. crystal structure of the RABEX-5 catalytic core in complex with nucleotide-free RAB21, a key intermediate in the exchange reaction pathway PMID: 17450153
    20. Integration of TGFB and RAS signaling silences RABGEF1 and enhances growth factor-directed cell migration. PMID: 18160707

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  • 亚细胞定位：
    Cytoplasm. Early endosome. Recycling endosome.
  • 数据库链接：

    HGNC: 17676

    OMIM: 609700

    KEGG: hsa:27342

    UniGene: Hs.530053