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RAB5B Antibody

  • 货号：
    CSB-PA019214ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RAB5B antibody at 1.66μg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Lane 4: 293T whole cell lysate
      Lane 5: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 24, 20 kDa
      Observed band size: 24, 31 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019214ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAB5B Polyclonal antibody
  • Uniprot No.：
    P61020
  • 基因名：
  • 别名：
    RAB5B antibody; Ras-related protein Rab-5B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-5B protein (1-215AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein transport. Probably involved in vesicular traffic.
  • 基因功能参考文献：
    1. Knockdown of RAB5B inhibited cell proliferation, migration and invasion in breast cancer stem cell-like cells. MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells. PMID: 29746865
    2. results suggest that LRRK2 kinase activity functions as a Rab5b GTPase activating protein and thus, negatively regulates Rab5b signalling PMID: 25605758
    3. combined genetic association studies in women from China/Netherlands/United States: Data suggest that an SNP in RAB5B locus (rs705702) and SNPs in other proteins are associated with polycystic ovary syndrome across ethnic differences. [META-ANALYSIS] PMID: 24106282
    4. study shows expression of GTPase-deficient Rab5b in NRK cells results in sequential formation of 3 distinct types of endosomes; study suggests regulatory role for Rab5 in early & late endocytic pathway of membrane trafficking in coordination with PI(3)K PMID: 17927960
    5. Results suggest that LRRK2, in conjunction with its interaction with Rab5b, plays an important role in synaptic function by modulating the endocytosis of synaptic vesicles. PMID: 18445495

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 数据库链接：

    HGNC: 9784

    OMIM: 179514

    KEGG: hsa:5869

    STRING: 9606.ENSP00000353444

    UniGene: Hs.157659