RAB40AL Antibody
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货号:CSB-PA019203LA01HU
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规格:¥440
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促销:
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图片:
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Immunofluorescence staining of MCF-7 cells with CSB-PA019203LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) RAB40AL Polyclonal antibody
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Uniprot No.:P0C0E4
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基因名:RAB40AL
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别名:RAB40AL antibody; RLGP antibody; Ras-related protein Rab-40A-like antibody; Ras-like GTPase antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Ras-related protein Rab-40A-like protein (1-88AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,RAB40AL Antibody (CSB-PA019203LA01HU),的标记方式是Non-conjugated。对于RAB40AL Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IF
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推荐稀释比:
Application Recommended Dilution IF 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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基因功能参考文献:
- Our findings are inconsistent with a causative effect of RAB40AL p.D59G on cognitive impairment combined with severe to profound bilateral hearing loss but indicate that p.D59G is a common genetic variation. PMID: 25370018
- Data question the role of RAB40AL mutation as a disease-causing change and the involvement of RAB40AL in Martin-Probst syndrome. PMID: 25044830
- We herein present an unrelated 20-year-old male with similar manifestations also with p.D59G in the RAB40AL gene, which supports the existence of this condition previously coined as Martin-Probst syndrome PMID: 24863632
- This is the first study to show that mutation of RAB40AL is associated with a human disorder. PMID: 22581972
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相关疾病:Mental retardation, X-linked, syndromic, Martin-Probst type (MRXSMP)
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亚细胞定位:Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Mitochondrion.
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蛋白家族:Small GTPase superfamily, Rab family
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组织特异性:Expressed in brain, lung, heart, skeletal muscle, kidney and liver. Highest expression in brain. Expressed in fetal brain and kidney.
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数据库链接:
HGNC: 25410
OMIM: 300405
KEGG: hsa:282808
STRING: 9606.ENSP00000218249
UniGene: Hs.449517
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