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RAB3GAP2 Antibody

  • 货号：
    CSB-PA872480LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate
      All lanes: RAB3GAP2 antibody at 5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 156, 24 kDa
      Observed band size: 110, 130, 150 kDa
    • IHC image of CSB-PA872480LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA872480LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAB3GAP2 Polyclonal antibody
  • Uniprot No.：
    Q9H2M9
  • 基因名：
    RAB3GAP2
  • 别名：
    RAB3GAP2 antibody; KIAA0839 antibody; Rab3 GTPase-activating protein non-catalytic subunit antibody; RGAP-iso antibody; Rab3 GTPase-activating protein 150 kDa subunit antibody; Rab3-GAP p150 antibody; Rab3-GAP150 antibody; Rab3-GAP regulatory subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rab3 GTPase-activating protein non-catalytic subunit protein (277-387AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RAB3GAP2 Antibody (CSB-PA872480LA01HU)，的标记方式是Non-conjugated。对于RAB3GAP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872480LB01HU RAB3GAP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA872480LC01HU RAB3GAP2 Antibody, FITC conjugated
    Biotin CSB-PA872480LD01HU RAB3GAP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
  • 基因功能参考文献：
    1. functionally severe RAB3GAP2 mutations cause Warburg Micro syndrome while hypomorphic RAB3GAP2 mutations can result in the milder Martsolf phenotype PMID: 20967465
    2. Data show that at chemical synapses, Rab3 performs specific functions in synpatic vesicle exocytosis. PMID: 18485483
    3. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator RAB3GAP2 occurs in a GTP-dependent manner through MADD. PMID: 18849981
  • 相关疾病：
    Martsolf syndrome (MARTS); Warburg micro syndrome 2 (WARBM2)
  • 亚细胞定位：
    Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
  • 蛋白家族：
    Rab3-GAP regulatory subunit family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 17168

    OMIM: 212720

    KEGG: hsa:25782

    STRING: 9606.ENSP00000351832

    UniGene: Hs.654849