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RAB34 Antibody

  • 中文名称：
    RAB34兔多克隆抗体
  • 货号：
    CSB-PA087223
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using RAB34 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAB34 Polyclonal antibody
  • Uniprot No.：
    Q9BZG1
  • 基因名：
    RAB34
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human RAB34.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transport protein involved in the redistribution of lysosomes to the peri-Golgi region. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
  • 基因功能参考文献：
    1. The present study demonstrated that RAB34 plays an important role in the initiation and progression of hepatocellular carcinoma (HCC). Our results suggest a new therapeutic target for the clinical treatment of HCC. PMID: 29048615
    2. Rab34 activity is modulated by SopD2 and is required for maturation of the Salmonella containing vacuole. PMID: 28185347
    3. NARR is ubiquitously expressed and resides in nucleoli where it colocalizes with ribosomal DNA gene clusters. PMID: 21586586
    4. MMP19 were positively correlated with RAB34. PMID: 25501506
    5. Although Rab34 regulates both lysosomal positioning and lysosome to phagosome fusion, the latter effect is not due to the regulation of the cytoplasmic accessibility of lysosomes to phagosomes by Rab34. PMID: 23871933
    6. Rab36 may regulate the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34. PMID: 19961360
    7. Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34, mediating lysosome-Golgi trafficking. PMID: 16138900
    8. define Rab34 as a novel member of the secretory pathway acting at the Golgi PMID: 17881736
    9. B coxsackievirus entry depends on occludin and require the activity of Rab34, Ras, and Rab5, GTPases known to regulate macropinocytosis. PMID: 18005733
    10. mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of DN. PMID: 19641095

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 数据库链接：

    HGNC: 16519

    OMIM: 610917

    KEGG: hsa:83871

    STRING: 9606.ENSP00000410403

    UniGene: Hs.301853