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RAB11FIP2 Antibody

  • 货号：
    CSB-PA437749
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from A549 cells, COLO cells, HUVEC cells and MCF-7 cells, using RAB11FIP2 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAB11FIP2 Polyclonal antibody
  • Uniprot No.：
    Q7L804
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human RAB11FIP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.
  • 基因功能参考文献：
    1. miR-142-3p, a microRNA enriched in exosomes during acute cellular rejection, is transferred to endothelial cells and compromises endothelial barrier function via down-regulation of RAB11FIP2. PMID: 28073833
    2. an interaction of Eps15 and Rab11-FIP2 at the appropriate time and location in polarizing cells is necessary for proper establishment of epithelial polarity. PMID: 28228550
    3. Our data suggested a potential role of Rab11-FIP2 in tumor progression and provided novel insights into the mechanism of how Rab11-FIP2 positively regulated cell migration and invasion in CRC cells. PMID: 26792722
    4. our findings reveal a novel mechanism underlying the role of Rab11-FIP2 in gastric cancer dissemination PMID: 26502090
    5. Rab11-FIP2 binding to MYO5B is essential for vesicular trafficking in Hela and MDCK cells. PMID: 24372966
    6. The recruitment of FIP2 is specific since other members of the Rab11-Family of Interacting Proteins do not associate with the chlamydial inclusions. PMID: 23006599
    7. Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane PMID: 22420646
    8. Rab11-FIP2 functions downstream of Rab11 in endosomal trafficking. PMID: 11994279
    9. Rab11-FIP2 regulates trafficking at multiple points within the apical recycling system of polarized cells PMID: 17626244
    10. the FIP2 C2 mutant caused a failure at the final budding step in the RSV virus life cycle PMID: 18621683
    11. Phosphorylation of Rab11-FIP2 on serine 227 by MARK2 regulates an alternative pathway modulating the establishment of epithelial polarity PMID: 16775013

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  • 亚细胞定位：
    Cell projection, phagocytic cup. Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
  • 数据库链接：

    HGNC: 29152

    OMIM: 608599

    KEGG: hsa:22841

    STRING: 9606.ENSP00000347839

    UniGene: Hs.173656