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RAB11FIP1 Antibody

  • 货号：
    CSB-PA060181
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q6WKZ4
  • 基因名：
  • 别名：
    FLJ22524 antibody; FLJ22622 antibody; HGNC:30265 antibody; MGC78448 antibody; No Rab11 binding protein 1A antibody; NOEL1A antibody; Rab coupling protein antibody; Rab effector protein antibody; Rab interacting recycling protein antibody; Rab-coupling protein antibody; RAB11 family interacting protein 1 (class I) antibody; Rab11 family interacting protein 1D antibody; Rab11 family-interacting protein 1 antibody; Rab11 FIP1 antibody; Rab11-FIP1 antibody; RAB11FIP1 antibody; RCP antibody; RFIP1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Rab11-FIP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.
  • 基因功能参考文献：
    1. Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart. PMID: 28294115
    2. The article focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides. (Review) PMID: 27658318
    3. High RCP expression is associated with lung metastasis in ovarian cancer. PMID: 27524413
    4. our findings indicate that FIP1C acts as a tumor suppressor in the context of ErbB2-positive breast cancer PMID: 26933086
    5. Findings suggest that overexpression of micro ribonucleic acid-93 (miR-93) via targeting RAB11 family interacting protein (RAB11FIP1) as an early event plays an important role in oncogenesis of cervical cancer. MiR-93 and its target protein RAB11FIP1 may be potential therapeutic targets for cervical cancer and its precursors. PMID: 27279231
    6. REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11. PMID: 26745340
    7. Rab11-FIP1A associates with and regulates trafficking at an early step in the process of membrane recycling PMID: 26790954
    8. GTPase Rab11, but not Rab4, is involved in the recycling of hERG channels. PMID: 26152716
    9. We find that Rab14 indeed binds to RCP, albeit with reduced affinity relative to conventional Rab11-FIP and Rab25-FIP complexes. However, in vivo, Rab11 recruits RCP onto biological membranes. PMID: 26032412
    10. rab11 effector protein FIP1 regulates adiponectin trafficking and secretion PMID: 24040321
    11. Mitochondrial remodeling was associated with increased proximity between Rab11a and mitochondrial membranes, changes in fusion-fission dynamics, and mitochondrial relocalization of the Drp1, which was regulated by the Rab11a effector protein FIP1/RCP. PMID: 24302731
    12. findings support a model for HIV-1 Env incorporation in which specific targeting to the particle assembly microdomain on the plasma membrane is mediated by FIP1C and Rab14 PMID: 23592992
    13. These findings suggest that Rab11-FIP1 proteins participate in spatially and temporally distinct steps of the recycling process along a complex and dynamic tubular network in which Rab11-FIPs occupy discrete domains PMID: 23283983
    14. Rab11 is differentially phosphorylated by distinct PKC isoenzymes; this post-translational modification might be a regulatory mechanism of intracellular trafficking. PMID: 22188018
    15. results suggest that Rab5 is involved in CB2 endocytosis and that internalized receptors are recycled via a Rab11 associated pathway rather than the rapid Rab4 associated pathway. PMID: 21640764
    16. FIP1/RCP binding to Golgin-97 is required for tethering and fusion of recycling endosome-derived retrograde transport vesicles to the trans-Golgi network. PMID: 20610657
    17. An interaction with Rab11 is necessary for long-range targeting of beta1 integrins to the growth cone along axons and in neurons. PMID: 20810886
    18. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein PMID: 11786538
    19. Receptor cell surface expression and endocytosis experiments reveal that the small GTPase Rab11 protein is a determinant factor in controlling thromboxane A2 receptor beta isoform recycling back to the cell surface. PMID: 15134434
    20. RCP functions primarily as a Rab11 binding protein that regulates protein sorting in tubular endosomes. PMID: 15181150
    21. Rab11, rather than Rab4, mediates the intracellular localisation of RCP. PMID: 15280022
    22. Acting as an intermediate between Rab4 and Rab11, RCP regulates membrane flux along the phagocytic pathway via recycling events. PMID: 15355514
    23. once the Rab11/RCP-regulated cargo has been delivered from the endocytic recycling compartment to the plasma membrane, RCP is inactivated by calpain-mediated proteolysis PMID: 15769254
    24. Rab11 and microtubules maintain the proper distribution of the subapical AQP2 storage compartment, and actin filaments regulate the trafficking of AQP2 from early endosomes to the storage compartment. PMID: 16049696
    25. Results describe the endometrial expression of Rab coupling protein and its hormonal regulation. PMID: 16216915
    26. identified eight alternatively spliced Rab11-FIP1 gene transcripts from human chromosome 8 PMID: 16920206
    27. RCP provides a scaffold that promotes the physical association and coordinate trafficking of alpha5beta1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices. PMID: 18838556
    28. RCP is a human breast cancer-promoting gene with Ras-activating function. PMID: 19620787

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  • 亚细胞定位：
    Recycling endosome. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).; [Isoform 2]: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).
  • 组织特异性：
    Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.
  • 数据库链接：

    HGNC: 30265

    OMIM: 608737

    KEGG: hsa:80223

    STRING: 9606.ENSP00000331342

    UniGene: Hs.191179