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QARS Antibody

  • 货号：
    CSB-PA019132DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Glutamine--tRNA ligase antibody at 2μg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 88, 87 kDa
      Observed band size: 88 kDa
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA019132DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019132DSR1HU at dilution of 1:100
    • Immunoprecipitating QARS in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA019132DSR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA019132DSR1HU (4μg) + Hela whole cell lysate (500μg)
      Lane 3: Hela whole cell lysate (20μg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) QARS Polyclonal antibody
  • Uniprot No.：
    P47897
  • 基因名：
    QARS
  • 别名：
    GlnRS antibody; Glutamine tRNA ligase antibody; Glutamine tRNA synthetase antibody; Glutamine--tRNA ligase antibody; Glutaminyl tRNA ligase antibody; Glutaminyl tRNA synthetase antibody; Glutaminyl-tRNA synthetase antibody; PRO2195 antibody; QARS antibody; SYQ_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glutamine--tRNA ligase protein (1-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Glutamine--tRNA ligase. Plays a critical role in brain development.
  • 基因功能参考文献：
    1. patient's fibroblasts demonstrated markedly reduced QARS amino acylation activity in vitro PMID: 28620870
    2. hcmv-miR-US4-1 may involve in promoting cell apoptosis and benefiting discharge of infectious virus particles via down-regulation of QARS in HCMV-infected HELF cells. PMID: 27240979
    3. Pathological mutations mapping in the N-terminal domain alter the domain structure, and decrease catalytic activity and stability of GlnRS, whereas missense mutations in the catalytic domain induce misfolding of the enzyme. PMID: 26869582
    4. Data indicate compound heterozygous mutations [c.169T>C (p.Tyr57His) and c.1485dup (p.Lys496*)] in QARS, which encodes glutaminyl-tRNA synthetase, in two siblings with early-onset epileptic encephalopathy (EOEE). PMID: 25471517
    5. interactions between the N-terminal domains of ArgRS and AIMP1 are important for the catalytic and noncatalytic activities of ArgRS and for the assembly of the higher-order MSC protein complex with ArgRS-GlnRS-AIMP1 PMID: 25288775
    6. results highlight the importance of QARS during brain development and that epilepsy due to impairment of QARS activity is unusually severe in comparison to other aminoacyl-tRNA synthetase disorders PMID: 24656866
    7. Data indicate that glutaminyl-tRNA synthetase splice variant GlnRSDeltaiABD was present in exosomes extruded from Jurkat cells and functional in protein synthesis. PMID: 24003230

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  • 相关疾病：
    Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)
  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 组织特异性：
    Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate.
  • 数据库链接：

    HGNC: 9751

    OMIM: 603727

    KEGG: hsa:5859

    STRING: 9606.ENSP00000307567

    UniGene: Hs.79322