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Pka-C1 Antibody

  • 货号：
    CSB-PA318954LA01DLU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Drosophila melanogaster Pka-C1 Polyclonal antibody
  • Uniprot No.：
    P12370
  • 基因名：
    Pka-C1
  • 别名：
    Pka-C1 antibody; CdkA antibody; DC0 antibody; CG4379 antibody; cAMP-dependent protein kinase catalytic subunit 1 antibody; PKA C antibody; EC 2.7.11.11 antibody; Protein kinase DC0 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Drosophila melanogaster
  • 免疫原：
    Recombinant Drosophila melanogaster cAMP-dependent protein kinase catalytic subunit 1 protein (2-353AA)
  • 免疫原种属：
    Drosophila melanogaster
  • 标记方式：
    Non-conjugated

    本页面中的产品，Pka-C1 Antibody (CSB-PA318954LA01DLU)，的标记方式是Non-conjugated。对于Pka-C1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA318954LB01DLU Pka-C1 Antibody, HRP conjugated ELISA
    FITC CSB-PA318954LC01DLU Pka-C1 Antibody, FITC conjugated
    Biotin CSB-PA318954LD01DLU Pka-C1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.
  • 基因功能参考文献：
    1. Hedgehog signalling activation causes PKA to switch its substrates from Ci to Smo within the Hh signalling complex. PMID: 25289679
    2. tightly controlled dose-dependent intra-neuronal PKA activity levels are critical in determining the dendritic arbor complexity, one of the possible ways being through the regulation of organelle distribution. PMID: 25017992
    3. Alpha- NAC is a substrate of PKA following Parathyroid Hormone signaling. PMID: 24550008
    4. that manipulations that increase cAMP/PKA signaling in adipokinetic hormone (AKH)-producing cells at the base of the neuroendocrine ring gland restore the dNf1 growth deficiency. PMID: 24278035
    5. Acute expression of protein kinase A inhibitory peptide in aged animals is sufficient to reverse age-related memory impairment in wild-type animals. PMID: 21084612
    6. Two-dimensional gel electrophoresis, (32)P labelling and immunodetection show that "in vitro" PKA phosphorylates the serine in the C-terminus of the NDUFS4 subunit in isolated bovine complex I. PMID: 20433953
    7. Its signaling underlies age-related memory impairment.(review) PMID: 18646611
    8. We found that decreased PKA activity in neurons rendered flies insensitive to the wake-promoting effects of octopamine. PMID: 18799671

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  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
  • 组织特异性：
    More abundant in adult head than adult body.
  • 数据库链接：

    KEGG: dme:Dmel_CG4379

    STRING: 7227.FBpp0079448

    UniGene: Dm.2136