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  4. Phospho-VAV3 (Y173) Antibody

Phospho-VAV3 (Y173) Antibody

  • 货号：
    CSB-PA006523
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of JK cells using Phospho-Vav3 (Y173) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKW4
  • 基因名：
  • 别名：
    FLJ40431 antibody; Guanine nucleotide exchange factor VAV3 antibody; Protein vav 3 antibody; Protein vav3 antibody; RGD1565941 antibody; VAV 3 antibody; Vav 3 guanine nucleotide exchange factor antibody; VAV 3 oncogene antibody; VAV 3 protein antibody; VAV-3 antibody; Vav3 antibody; VAV3 oncogene antibody; VAV3 protein antibody; VAV3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human Vav3 around the phosphorylation site of Y173.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion.
  • 基因功能参考文献：
    1. The N-terminal truncated Vav3.1 may be decisively involved in mechanisms causing genuine multi-drug resistance. PMID: 29194596
    2. VAV3 polymorphisms associate with cardiovascular risk factors and target organ damage. PMID: 28157227
    3. High VAV3 variant expression is associated with endometrial cancer. PMID: 30083818
    4. Results identified the diffuse B-cell lymphoma homology (DH) domain of Vav3 that interacts with the N-terminal region of AR-V7 (splice variants) and increases its expression in castration-resistant prostate cancer (CRPC). This interaction disrupted AR-V7 interaction with other AR coactivators like Src1 and Vav2. PMID: 28811363
    5. We then explore the consequences of phorbol ester binding to a modified Vav3 in which the C1 domain has been altered to allow phorbol ester binding. We find both disruption of the guanyl nucleotide exchange activity of the modified Vav 3 as well as a shift in localization to the membrane upon phorbol ester treatment. PMID: 28927664
    6. Overexpression of Vav3 is an independent risk factor for prognosis of gastric cancer, and can be used as a prognostic indicator. PMID: 28285969
    7. Vav3 is a novel TRAF6 interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex. PMID: 27507811
    8. this study shows that the anti-tumor effects of astragaloside IV are mediated by the downregulation of Vav3-mediated Rac1/MAPK activation PMID: 27930970
    9. Our results indicated that individuals carrying the VAV3 rs7528153 TT genotype were at a significantly increased risk of developing Paget's Disease of Bone PMID: 27172236
    10. Vav3 was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and thereby increased the motility and invasiveness of pancreatic ductal adenocarcinoma cells PMID: 27453460
    11. Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK pathway PMID: 26695150
    12. Data show that microRNA miR-499-5p targeted 3' untranslated regions (3'-UTR) of vav 3 oncogene protein (VAV3). PMID: 26972445
    13. Results found that OSR2, VAV3, and PPFIA3 were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC. PMID: 27143812
    14. Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels. PMID: 26337083
    15. VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma. PMID: 25715123
    16. VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC PMID: 25791293
    17. discrete and different functions of VAV3.1 in metastasis and tumorigenesis are conceivable. PMID: 25964534
    18. Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK signaling pathway. PMID: 25430880
    19. This study proposes VAV3 as a biomarker and a rationale for its use as a signaling target to prevent and/or overcome resistance to endocrine therapy in breast cancer. PMID: 24886537
    20. A new genome-wide significant association between VAV3 and IgA nephropathy. PMID: 25305756
    21. Data indicate that Vav3 oncogene protein plays a crucial role in prostate cancer growth and malignant behavior, and could be a potential therapeutic target. PMID: 23403204
    22. Vav3 is involved in the proliferation, migration, and invasion of gastric cancer cell as a tumor oncogene PMID: 24072493
    23. Interrupting Vav3 signaling enhances docetaxel-induced apoptosis in LNCaP cells under chronic hypoxia by inhibiting the PI3K/Akt, ERK, and AR signaling pathways. PMID: 23566222
    24. VAV3 can be seen as novel candidate gene for schizophrenia in which both rare and common variants may be related to increased genetic risk in a Japanese population. rs1410403 might affect the volume of the left temporal gyri. PMID: 22416266
    25. Two variants of VAV2 and VAV3, rs2156323 and rs2801219, respectively, were identified in Japanese patients with primary open angle glaucoma, normal tension glaucoma, and developmental glaucoma. PMID: 23402756
    26. These data, which demonstrate physical and functional interactions between Vav3 and an AR splice variant, provide insights into the mechanisms by which Vav3 exploits and enhances AR signaling in the progression to castration-resistant prostate cancer. PMID: 23023561
    27. analysis of a novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth PMID: 23281476
    28. Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis. PMID: 23033535
    29. Data indicate that Vav2 and Vav3 controlled a vast transcriptional program in breast cancer cells through mechanisms that were shared between the two proteins, isoform-specific or synergistic. PMID: 23033540
    30. Study suggests that overexpression of guanine nucleotide exchange factor Vav3 can be a useful marker for predicting the outcome of patients with gastric cancer and that Vav3 targeting can represent a potential modality for treating gastric cancer. PMID: 22544459
    31. Novel associations for hypothyroidism and autoimmune risk loci include SNPs near the VAV3 gene. PMID: 22493691
    32. Among patients with stage IIB or earlier prostate cancer, higher Vav3 expression correlated with lower cumulative biochemical failure-free survival, suggesting that Vav3 may represent a prognostic marker for posttreatment recurrence of prostate cancer. PMID: 22659453
    33. Data show the importance of Vav3 in castration-resistant prostate cancer (CRPC) and define a nuclear function of Vav3 in regulating androgen receptor (AR) activity. PMID: 21765461
    34. These data revealed that Vav3 overexpression as an additional underlying mechanism contributes to elevated sPLA2-IIa expression in prostate cancer PMID: 21455584
    35. Vav3 may enhance non-genomic AR activity via PI3K-Akt signaling in addition to AR transcriptional activity, showing that it may have a role in androgen-independent growth in prostate cancer PMID: 20126983
    36. present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. PMID: 20463313
    37. Data strongly suggest that VAV2 and VAV3 genes are susceptibility loci in Japanese primary open-angle glaucoma. PMID: 20140222
    38. Vav3 regulates the B cell responses by promoting the sustained production of PIP3 and thereby calcium flux PMID: 11805146
    39. We present here a novel stimulatory mechanism of Vav3 in which APS directly relieves the autoinhibitory CH domain and furthermore enhances its tyrosine phosphorylation by Lck. PMID: 12400014
    40. results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI PMID: 15456756
    41. TCR-induced association of Vav3 with SLP-76 is required for its membrane/IS localization and function PMID: 15708849
    42. Vav3 levels rise during prostate cancer progression to androgen independence. PMID: 16384856
    43. Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer development and progression. PMID: 16762975
    44. Constitutively active Vav3 mediates ligand-independent transcriptional activation and promotes nuclear localization pf the androgen receptor in prostate neoplsms. PMID: 18079321
    45. Findings suggest that Vav3 overexpression may aberrantly enhance ERalpha-mediated signaling axis and play a role in breast cancer development and/or progression. PMID: 18518979
    46. Data show that Trio, Ect2, and Vav3 are expressed at higher levels in glioblastoma versus low-grade glioma, and are involved in tumor cell migration and invasion. PMID: 19008376
    47. Proteins beta3 integrin, Vav3, Plekhm1, and Src, implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis. PMID: 19546854

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  • 组织特异性：
    Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, f
  • 数据库链接：

    HGNC: 12659

    OMIM: 605541

    KEGG: hsa:10451

    STRING: 9606.ENSP00000359073

    UniGene: Hs.267659