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  4. Phospho-SHB (Y246) Antibody

Phospho-SHB (Y246) Antibody

  • 货号：
    CSB-PA000618
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using Phospho-Shb (Y246) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15464
  • 基因名：
    SHB
  • 别名：
    bA3J10.2 antibody; OTTHUMP00000021397 antibody; RP11 3J10.8 antibody; RP113J10.8 antibody; SH2 domain containing adapter protein B antibody; SH2 domain-containing adapter protein B antibody; SHB (Src homology 2 domain containing) adaptor protein B antibody; SHB adaptor protein (a Src homology 2 protein) antibody; SHB adaptor protein antibody; Shb antibody; SHB_HUMAN antibody; Src homology 2 domain containing adaptor protein B antibody; Src homology 2 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human Shb around the phosphorylation site of Y246.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • 基因功能参考文献：
    1. This article provides a resource for the available molecular tools that can be used in future research on Shb PMID: 29194461
    2. It is concluded that tumor SHB gene expression relates to acute myeloid leukemia survival PMID: 28982308
    3. SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types. [review] PMID: 26489764
    4. SH2-Bbeta is a Rac-binding protein that regulates cell motility PMID: 11786545
    5. Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells (SLP-76) PMID: 12084069
    6. SHB links IL2 receptor for signal transduction and mediates apoptosis PMID: 12200137
    7. Taken together, our results suggest that SH2-Bbeta is a new signaling molecule involved in GDNF-induced neurite outgrowth. PMID: 16569669
    8. It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 and insulin in EBs and that such cells can be separated by FACS. PMID: 16630561

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 10838

    OMIM: 600314

    KEGG: hsa:6461

    STRING: 9606.ENSP00000366936

    UniGene: Hs.521482