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  4. Phospho-SGOL1 (S14) Antibody

Phospho-SGOL1 (S14) Antibody

  • 货号：
    CSB-PA007468
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q5FBB7
  • 基因名：
    SGO1
  • 别名：
    hSgo 1 antibody; hSgo1 antibody; NY BR 85 antibody; Serologically defined breast cancer antigen NY BR 85 antibody; Serologically defined breast cancer antigen NY-BR-85 antibody; SGO 1 antibody; SGO antibody; SGO L1 antibody; SGO1 antibody; SGOL 1 antibody; SGOL1 antibody; SGOL1_HUMAN antibody; Shugoshin 1AB protein antibody; Shugoshin 1CD protein antibody; Shugoshin 1EFprotein antibody; Shugoshin 1GH protein antibody; Shugoshin 1KL protein antibody; Shugoshin like 1 (S. pombe) antibody; Shugoshin like 1 antibody; Shugoshin-like 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from Human Sgo1 around the phosphorylation site of S14.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
  • 基因功能参考文献：
    1. Aurora B kinase interacts with and phosphorylates Sgo1. Aurora B-mediated phosphorylation of Sgo1 regulates the distribution of Sgo1 between centromeres and chromosome arms. PMID: 25451264
    2. SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. PMID: 24146025
    3. Cohesin complex is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1-dependent PP2A recruitment. PMID: 26365192
    4. Sgo1 co-recruits Aurora B and PP2A to centromeres of unattached chromosomes. PMID: 25892238
    5. Data indicate essential role of shugoshin-like protein 1 (Sgo1) in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for hepatocellular carcinoma (HCC). PMID: 25638162
    6. Results show that Sgo1 is first recruited to kinetochores by H2A-pT120, and the kinetochore-bound Sgo1 is released by centromeric transcription. PMID: 26190260
    7. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. PMID: 25282101
    8. Bub1-mediated H2A phosphorylation penetrates kinetochores and that this histone mark contributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation. PMID: 24055156
    9. The most significant association with MaxDrinks was observed with SNP rs11128951 (p = 4.27 x 10(-8)) near SGOL1 gene at 3p24.3. PMID: 23953852
    10. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. PMID: 23850494
    11. SGO1 promotes multidrug resistance of gastric cancer cells and may be useful as a novel therapeutic target for preventing or reversing multidrug resistance PMID: 23564482
    12. Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth PMID: 22161216
    13. These results suggest that SGOL1-P1 may function as a negative factor to native SGOL1, and that abundant expression of SGOL1-P1 may be responsible for chromosomal instability. PMID: 21532624
    14. HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres. PMID: 21346195
    15. Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export. PMID: 20384790
    16. Bub1 protects centromeric cohesion through Shugoshin in mitosis PMID: 15604152
    17. A shugoshin-like protein associates with centromeres during prophase and disappears at the onset of anaphase PMID: 15737064
    18. a specific subtype of serine/threonine protein phosphatase 2A (PP2A) associates with human shugoshin PMID: 16541025
    19. Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1. PMID: 16580887
    20. depletion of Sgo1 results in precocious chromosomal segregation and massive mitotic arrest PMID: 16628005
    21. Mutation in the SGOL1 D-box causes transient metaphase arrest, and leads to defects in chromosome alignment and segregation. PMID: 17448445
    22. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. PMID: 17617734
    23. Results suggest that NEK2A-mediated phosphorylation of Sgo1 (SGOL1) provides a link between centromeric cohesion and spindle microtubule attachment at the kinetochores. PMID: 17621308
    24. Centriole splitting induced by Sgo1 depletion or expression of a dominant negative mutant is suppressed by ectopic expression of sSgo1 or by Plk1 knockdown. PMID: 18331714
    25. findings suggest that hSgo1-downregulated colorectal cancers have a clinicopathological character of chromosome instability (CIN), and hSgo1 downregulation leads to CIN in colorectal cancer cells. PMID: 18635744
    26. the direct link between HP1 and shugoshin is conserved in human cells PMID: 18716626
    27. the spindle checkpoint kinase Bub1 contributes to the maintenance of Sgo1 steady-state protein levels in an APC/C-independent mechanism. PMID: 19015261
    28. Report structure and function of the PP2A-shugoshin interaction. PMID: 19716788
    29. A comprehensive review of Sgo1 function in eukaryote at meiosis and mitosis. PMID: 16112668

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  • 相关疾病：
    Chronic atrial and intestinal dysrhythmia (CAID)
  • 亚细胞定位：
    Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Shugoshin family
  • 组织特异性：
    Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested.
  • 数据库链接：

    HGNC: 25088

    OMIM: 609168

    KEGG: hsa:151648

    STRING: 9606.ENSP00000263753

    UniGene: Hs.105153